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ABAT Recombinant Monoclonal Antibody

  • 中文名稱：
    ABAT重組抗體
  • 貨號(hào)：
    CSB-RA242969A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA242969A0HU diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    ABAT Recombinant Monoclonal Antibody（Code: CSB-RA242969A0HU）是針對(duì)γ-氨基丁酸轉(zhuǎn)氨酶（ABAT）開發(fā)的高特異性抗體，適用于酶聯(lián)免疫吸附實(shí)驗(yàn)（ELISA）和免疫組化（IHC）檢測(cè)。ABAT是GABA代謝通路中的關(guān)鍵酶，負(fù)責(zé)催化γ-氨基丁酸轉(zhuǎn)化為琥珀酸半醛，在維持神經(jīng)遞質(zhì)平衡和中樞神經(jīng)系統(tǒng)功能中發(fā)揮重要作用。本抗體通過重組技術(shù)制備，具有優(yōu)異的批間一致性和低交叉反應(yīng)性，經(jīng)多種實(shí)驗(yàn)驗(yàn)證可特異性識(shí)別天然及重組ABAT蛋白。在IHC實(shí)驗(yàn)中，推薦使用1:50至1:200的稀釋比例，能夠清晰顯示組織樣本中ABAT的定位與表達(dá)水平，適用于神經(jīng)生物學(xué)研究、代謝相關(guān)疾病模型的蛋白表達(dá)分析以及神經(jīng)退行性疾病機(jī)制探索等科研領(lǐng)域。該產(chǎn)品為研究者提供可靠的工具，可用于探究ABAT在神經(jīng)信號(hào)調(diào)控、能量代謝和病理狀態(tài)中的分子作用，但不適用于臨床診斷或治療用途。
  • Uniprot No.：
  • 基因名：
    ABAT
  • 別名：
    4-aminobutyrate aminotransferase, mitochondrial (EC 2.6.1.19) ((S)-3-amino-2-methylpropionate transaminase) (EC 2.6.1.22) (GABA aminotransferase) (GABA-AT) (Gamma-amino-N-butyrate transaminase) (GABA transaminase) (GABA-T) (L-AIBAT), ABAT, GABAT
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human ABAT
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    5B6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
  • 基因功能參考文獻(xiàn)：
    1. This study utilized ER+ IBC to identify a metagene including ABAT and STC2 as predictive biomarkers for endocrine therapy resistance. PMID: 25771305
    2. A-to-G transition at nucleotide 754 of the human ABAT gene identified in lymphoblast cDNA (c.754A>G) results in substitution of an invariant arginine at amino acid 220 by lysine (p.Arg220Lys). This point mutation results in destabilization of the binding of pyridoxal-5'-phosphate to GABA-transaminase (required for transamination of GABA to succinic semialdehyde) and thus results in GABA-transaminase deficiency. PMID: 25485164
    3. Findings point to a possible role of ABAT gene-regulated GABA catabolism for an altered processing of somatosensory stimuli as a potential vulnerability marker for affective disorders. PMID: 22225676
    4. direct involvement of ABAT in pathways affecting lower esophageal sphincter (LES) control in gastro esophageal reflux disease PMID: 21552517
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20659789
    6. excessive prenatal GABA exposure in the central nervous system (CNS) is responsible for the clinical manifestations of GABA transaminase deficiency [case report] PMID: 20052547
    7. Marked differences in platelet uptake of GABA and activity of catabolic enzyme GABA-T between patients with generalized and localization-related epileptic syndromes. May indicate an impairment in function of brain GABAergic systems. PMID: 12694932
    8. results suggest that the Cys321 residue is essential for the catalytic function of GABAT, and that it is involved in the formation of a disulfide link between two monomers of human brain GABAT PMID: 15528998
    9. lysine 357 is essential for catalytic function of brain GABA transaminase, and is involved in binding PLP at the active site PMID: 15650327
    10. Analysis of the autistic disorder susceptibility locus suggests an association on chromosome 16p between GRIN2A and ABAT. PMID: 15830322

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  • 相關(guān)疾病：
    GABA transaminase deficiency (GABATD)
  • 亞細(xì)胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Class-III pyridoxal-phosphate-dependent aminotransferase family
  • 組織特異性：
    Liver > pancreas > brain > kidney > heart > placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23

    OMIM: 137150

    KEGG: hsa:18

    STRING: 9606.ENSP00000268251

    UniGene: Hs.336768