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ENPEP Recombinant Monoclonal Antibody

  • 中文名稱：
    ENPEP重組抗體
  • 貨號：
    CSB-RA552900A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA552900A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    ENPEP Recombinant Monoclonal Antibody（CSB-RA552900A0HU）是一款針對人源谷氨酰氨肽酶（ENPEP）的高特異性抗體，適用于酶聯(lián)免疫吸附實驗（ELISA）和免疫組織化學(xué)（IHC）檢測。ENPEP是一種膜結(jié)合金屬蛋白酶，參與血管緊張素代謝和細(xì)胞黏附過程，其表達(dá)水平與血管生成、腫瘤微環(huán)境調(diào)控及心血管功能密切相關(guān)。本產(chǎn)品通過重組表達(dá)技術(shù)制備，經(jīng)嚴(yán)格驗證可在IHC實驗中清晰顯示ENPEP蛋白在石蠟包埋組織中的定位分布，推薦使用稀釋比例為1:50-1:200，實驗數(shù)據(jù)表明其具有優(yōu)異的批間一致性、低交叉反應(yīng)性和高信噪比特性，能夠有效識別天然構(gòu)象的靶蛋白。該抗體適用于研究ENPEP在組織發(fā)育、腫瘤生物學(xué)或心血管疾病相關(guān)模型中的表達(dá)調(diào)控機(jī)制，為探索其在細(xì)胞外基質(zhì)重塑、病理微環(huán)境調(diào)控等領(lǐng)域的生物學(xué)功能提供可靠工具，滿足基礎(chǔ)科研中對蛋白定位及表達(dá)水平分析的需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Glutamyl aminopeptidase (EAP) (EC 3.4.11.7) (Aminopeptidase A) (AP-A) (Differentiation antigen gp160) (CD antigen CD249), ENPEP
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human Aminopeptidase A / CD249
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2G11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.
  • 基因功能參考文獻(xiàn)：
    1. We suggest that APA enzymatic activity affects tumor initiation and cancer malignancy in a TWIST-dependent manner PMID: 28177885
    2. The substrate Angiotensin II, the enzymes aminopeptidases-A, B, M as well as IRAP were detected in the jejunal mucosa. PMID: 26311161
    3. This study suggests a role for GAP in the neoplastic development of renal tumours and provides additional data for considering the activity and expression of this enzyme of interest in the diagnosis and prognosis of renal neoplasms. PMID: 24885240
    4. These results explain the calcium-modulated substrate specificity of APA in central hypertension regulation PMID: 23888046
    5. There was no significant alteration in plasma APA activity in the patients with Chagas disease or dilated cardiomyopathies, as compared with that in health controls PMID: 21697726
    6. Rieger syndrome with microdeletions including only the PITX2 and ENPEP (glutamyl aminopeptidase) genes. PMID: 17850355
    7. Data show that APA appears to be an essential enzyme in the control of blood pressure via degradation of Angiotensin II. PMID: 17990103
    8. Data show that aminopeptidase A (APA) plays important roles in the regulation of blood pressure under both the physiological and pathological conditions. PMID: 17999179
    9. Data show that brain aminopeptidases act upon Ang I, Ang II and Ang III in order to activate brain AT(1) receptors. PMID: 18188697
    10. rare and common variation in ENPEP may contribute to the development of renal and hypertensive disorders and warrants further study PMID: 18206321
    11. The presence of APA in several human brain nuclei sensitive to angiotensins and involved in blood pressure regulation suggests that APA in humans is an integral component of the brain renin angiotensin system. PMID: 18410507
    12. A novel nonsense polymorphism in the aminopeptidase-a gene was associated with hypertension among postmenopausal women, and those with marginal calcium and vitamin D intake. PMID: 18550936
    13. Angiotensin III and aminopeptidase A and N, related converting enzymes, contribute to cell proliferation of prostate cancer and may be implicated in cancer progression. PMID: 18677709
    14. Over-expressed APA drastically reduces, in a calcium dependent manner, full-length-Abeta but not amyloid-beta precursor protein (APP) intracellular domain in a cell-free model of Abeta production. PMID: 19187443
    15. The activity of glutamyl aminopeptidase was significally increased in head and neck squamous cell carcinoma tissue. PMID: 19373777

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Peptidase M1 family
  • 組織特異性：
    Expressed in choriocarcinoma cancer cell lines (at protein level). Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3355

    OMIM: 138297

    KEGG: hsa:2028

    STRING: 9606.ENSP00000265162

    UniGene: Hs.435765