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  4. Mono-methyl-Histone H2B type 2-E (R79) Recombinant Monoclonal Antibody

Mono-methyl-Histone H2B type 2-E (R79) Recombinant Monoclonal Antibody

  • 中文名稱：
    單甲基-組蛋白 H2B type 2-E (R79)重組抗體
  • 貨號：
    CSB-RA620981A79me1HU
  • 規(guī)格：
    ￥1320
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA620981A79me1HU是針對組蛋白H2B第二亞型E第79位精氨酸單甲基化修飾（H2B2E-R79me1）研發(fā)的重組單克隆抗體。該表觀遺傳修飾位點參與染色質(zhì)動態(tài)調(diào)控，可能通過影響核小體結(jié)構(gòu)與DNA修復(fù)機制、調(diào)控基因沉默等生物學(xué)過程發(fā)揮作用。本產(chǎn)品經(jīng)過ELISA平臺嚴(yán)格驗證，能特異性識別H2B2E-R79位點的單甲基化修飾，具有高親和力和低交叉反應(yīng)性，適用于定量檢測該修飾位點的動態(tài)變化。在科研領(lǐng)域可用于探究組蛋白甲基化在細(xì)胞周期調(diào)控、基因組穩(wěn)定性維持中的分子機制，或用于腫瘤發(fā)生、干細(xì)胞分化等疾病模型中表觀遺傳調(diào)控網(wǎng)絡(luò)的解析。該重組抗體采用單克隆制備技術(shù)，具有批次間高度一致性，支持ELISA實驗中的精確定量分析，為表觀遺傳學(xué)基礎(chǔ)研究提供可靠工具。建議使用者根據(jù)具體實驗體系優(yōu)化抗體工作濃度。
  • Uniprot No.：
  • 基因名：
    HIST2H2BE
  • 別名：
    HIST2H2BE antibody; H2BFQHistone H2B type 2-E antibody; Histone H2B-GL105 antibody; Histone H2B.q antibody; H2B/q antibody
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    A synthesized peptide
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    3E12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
  • 基因功能參考文獻(xiàn)：
    1. Findings uncover a novel function of let-7 miRNAs as regulators of H2B ubiquitylation, suggesting an additional mechanism whereby these miRNAs can exert their tumor-suppressive effects. PMID: 28604753
    2. Within the nucleus, PKC-theta; catalytic activity maintains the Ser536 phosphorylation on the p65 subunit of NF-kappaB (also known as RelA) and can directly influence chromatin accessibility at transcriptional memory genes by regulating H2B deposition. PMID: 27149922
    3. Study provides the first observation of the proteolytic processing of histones H2B and H3 in human hepatocytes where four different clipping sites were localized in H3 and one in H2B. PMID: 26424599
    4. Gene expression analysis identified deregulation of histone H2A and H2B genes in all four cell lines ;histone pathways are associated with epirubicin resistance PMID: 26852132
    5. The 2.7-A-resolution crystal structure of the human YL1-H2A.Z-H2B complex shows that YL1 binding, similarly to ANP32E binding, triggers an extension of the H2A.Z alphaC helix. PMID: 26974126
    6. CRL4(Wdr70) regulates H2B monoubiquitination and facilitates Exo1-dependent DNA repair resection. PMID: 27098497
    7. analysis of a functional hotspot on ubiquitin that is required for the stimulation of human Dot1 PMID: 26240340
    8. Results show that the cotranscriptional ubiquitylation of histone H2B suggests that it may be more intimately involved in ongoing nucleosome turnover in the wake of Pol II. PMID: 25049226
    9. H2B K34 ubiquitylation by the MOF-MSL complex is part of the protein networks involved in early steps of transcription elongation. PMID: 24837678
    10. Knockdown of EZH2 increased the ubiquitination level of H2BK120. PMID: 24339737
    11. Autoimmunity to isoAsp histone H2B suggests that this form of the autoantigen may be critical in the induction of anti-histone autoantibodies in human SLE. PMID: 22967069
    12. after H2B monoubiquitylation H2B is largely positioned at the exon-intron boundaries of highly expressed exons, and it demonstrates increased occupancy in skipped exons compared with flanking exons in the human genome PMID: 22421545
    13. cancerous cells in the tumor specimens. Taken together, our data suggest that glucose deficiency and loss of uH2B are novel properties of cancer cells in vivo, which may represent important regulatory mechanisms of tumorigenesis PMID: 22615809
    14. H2B and H4 histones were mobilized during herpes simplex virus 1 infection and became available to bind to viral genomes. PMID: 21994445
    15. Studies indicate that H2B monoubiquitylation is driven primarily by an E3 ubiquitin ligase composed of the two RING finger proteins RNF20 and RNF40. PMID: 21827756
    16. these data point at acetylation of Lysine 120 of H2B as an early mark of poised or active state and establish a temporal sequence between acetylation and mono-ubiquitination of this H2B residue. PMID: 21739721
    17. Protein phosphatase 2C gamma binds to/dephosporylates histone 2b to affect chromatin function. PMID: 17074886
    18. A redox-modulated direct p38/GAPDH-Oct-1 interaction nucleates the occupancy of the H2B promoter by the OCA-S complex, in which p36/LDH plays a critical role in the hierarchical organization of the complex. PMID: 18682386
    19. These studies establish the natural H2B ubiquitylation factors in human cells and also detail the mechanistic basis for H2B ubiquitylation and function during transcription PMID: 19410543
    20. NO-mediated H2B gene repression depends on modifications of endogenous PPAR ligands. PMID: 19425504

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Histone H2B family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4760

    OMIM: 601831

    KEGG: hsa:8349

    STRING: 9606.ENSP00000358151

    UniGene: Hs.2178