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NUDC Recombinant Monoclonal Antibody

  • 中文名稱：
    NUDC重組抗體
  • 貨號(hào)：
    CSB-RA906015A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, K562 whole cell lysate, 293T whole cell lysate, A549 whole cell lysate, Rat Brain whole cell lysate, Mouse Brain whole cell lysate
      All lanes: NUDC antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39 kDa
      Observed band size: 45 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA906015A0HU NUDC重組單克隆抗體是針對(duì)核分布蛋白C（NUDC）研發(fā)的高特異性科研試劑，適用于ELISA和Western Blot（WB）實(shí)驗(yàn)，其中WB推薦使用稀釋比例為1:500至1:5000。該抗體靶向的NUDC蛋白在細(xì)胞核遷移、紡錘體組裝及有絲分裂過(guò)程中發(fā)揮關(guān)鍵作用，其表達(dá)異常與細(xì)胞周期失調(diào)及腫瘤發(fā)生密切相關(guān)。經(jīng)多物種細(xì)胞裂解液及組織樣本驗(yàn)證，本產(chǎn)品可特異性識(shí)別天然構(gòu)象下的NUDC蛋白，檢測(cè)結(jié)果呈現(xiàn)單一清晰條帶，重復(fù)性優(yōu)異。嚴(yán)格的質(zhì)量控制體系確保了批次間的高一致性，適用于低豐度樣本檢測(cè)。科研人員可將其應(yīng)用于細(xì)胞分裂機(jī)制研究、腫瘤微環(huán)境分析或藥物靶點(diǎn)篩選等基礎(chǔ)研究領(lǐng)域，尤其為探究NUDC在癌癥進(jìn)展、神經(jīng)發(fā)育障礙中的分子機(jī)制提供可靠工具。該抗體適用于常規(guī)實(shí)驗(yàn)室條件下使用，滿足分子生物學(xué)及細(xì)胞生物學(xué)實(shí)驗(yàn)對(duì)精準(zhǔn)檢測(cè)的需求。
  • Uniprot No.：
  • 基因名：
    NUDC
  • 別名：
    Nuclear migration protein nudC (Nuclear distribution protein C homolog), NUDC
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    A synthesized peptide derived from human NUDC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    6C3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in neurogenesis and neuronal migration. Necessary for correct formation of mitotic spindles and chromosome separation during mitosis. Necessary for cytokinesis and cell proliferation.
  • 基因功能參考文獻(xiàn)：
    1. High expression of NUDC is associated with prostate cancer. PMID: 27959429
    2. the upregulation of miR-194 affects the hNUDC expression, leading to a downregulated expression of Mpl/ERK pathway proteins, and suppresses the mitosis and proliferation of NSCLC cells. PMID: 27035759
    3. NudC is co-localized with Aurora B at the midbody and co-immunoprecipitated with Aurora B in mitosis. results suggest that that dynamic phosphorylation of NudC by Aurora B regulates cytokinesis. PMID: 27074040
    4. NudC acetylation/deacetylation regulates mitotic progression and NudC deacetylation, likely through HDAC3, is critical for spindle function and chromosome congression. PMID: 24069238
    5. Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia in nasopharyngeal carcinoma. PMID: 21473139
    6. NudC may be involved in the regulation of LIS1 stability by its chaperone function. PMID: 20675372
    7. separate binding sites on the Mpl receptor for TPO and hNUDC identified PMID: 20529857
    8. Mpl plays an important and specific role in mediating hNUDC-induced megakaryocyte proliferation and differentiation. PMID: 19560457
    9. functions in mitosis and cytokinesis, in part by regulating microtubule organization at the midzone and midbody PMID: 12679384
    10. PLK1 phosphorylation of NudC plays an essential role in cytokinesis. PMID: 12852857
    11. Overexpression of NUDC inhibits prostatic neoplasm growth. PMID: 14676831
    12. In this study, we report the binding of hNUDC to the extracellular domain of the thrombopoietin receptor (Mpl) as detected by the yeast two-hybrid system, GST pull-down, and co-immunoprecipitation. PMID: 16088917
    13. NudC functions as both a substrate and a spatial regulator of Plk1 at the kinetochore to promote chromosome congression. PMID: 16860740
    14. hNUDC induced significant changes in cellular morphology in NIH 3T3 cells stably transfected with pMpl-EGFP. Interestingly, these morphological changes were characteristic of cells undergoing megakaryocyte differentiation. PMID: 17658515
    15. hNUDC induced a sustained activation of the extracellular signal-regulated protein kinases-1 and -2 (ERK1/2) as well as p38 mitogen-activated kinase (p38 MAPK) pathways PMID: 18288130

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  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton. Nucleus. Cytoplasm, cytoskeleton, spindle. Midbody.
  • 蛋白家族：
    NudC family
  • 組織特異性：
    Ubiquitous. Highly expressed in fetal liver, kidney, lung and brain. Highly expressed in adult pancreas, kidney, skeletal muscle, liver, lung, placenta, prostate, brain and heart.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8045

    OMIM: 610325

    KEGG: hsa:10726

    STRING: 9606.ENSP00000319664

    UniGene: Hs.263812