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PCYT1A Recombinant Monoclonal Antibody

  • 中文名稱：
    PCYT1A重組抗體
  • 貨號：
    CSB-RA213218A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: PCYT1A antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 42 kDa
      Observed band size: 42 kDa
    • Immunofluorescence staining of Hela Cells with CSB-RA213218A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA213218A0HU是針對PCYT1A靶點研發(fā)的重組單克隆抗體，經多種實驗驗證具有優(yōu)異性能。PCYT1A（磷酸膽堿胞苷酰轉移酶1A）是催化磷脂酰膽堿合成的限速酶，參與細胞膜形成、脂質代謝及信號轉導等基礎生物學過程。本抗體經ELISA驗證可特異性識別天然及重組PCYT1A蛋白，在Western Blot實驗中能清晰檢測內源性PCYT1A表達，推薦使用1:500-1:5000稀釋比例；免疫熒光實驗顯示其在細胞質中呈現(xiàn)特異性定位信號，推薦1:20-1:200稀釋范圍。該抗體采用重組表達技術制備，具有高親和力與批次間一致性，適用于探究PCYT1A在脂代謝調控、細胞膜動態(tài)平衡及相關疾病模型中的作用機制，可廣泛應用于生物化學、細胞生物學等領域的基礎研究，包括但不限于肝臟脂質穩(wěn)態(tài)研究、神經細胞膜功能分析以及代謝通路相互作用探索等實驗場景。
  • Uniprot No.：
  • 基因名：
    PCYT1A
  • 別名：
    Choline-phosphate cytidylyltransferase A (EC 2.7.7.15) (CCT-alpha) (CTP:phosphocholine cytidylyltransferase A) (CCT A) (CT A) (Phosphorylcholine transferase A), PCYT1A, CTPCT PCYT1
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human PCYT1A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    4F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis.
  • 基因功能參考文獻：
    1. There is no correlation between single PCYT1A rs712012 and PCYT1A rs7639752 polymorphisms and the incidence of intrauterine fetal death. PMID: 28509322
    2. PCYT1A mutations were identified in patients with isolated retinal dystrophy without any skeletal involvement from two Italian families. PMID: 28272537
    3. CCT contributes to phospholipid compositional homeostasis. [Review] PMID: 26165797
    4. PCYT1A-generated phosphatidylcholine has a role in the normal function of white adipose tissue and insulin action PMID: 24889630
    5. We report loss-of-function mutations in PCYT1A as the cause of spondylometaphyseal dysplasia with cone-rod dystrophy. PMID: 24387990
    6. Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy PMID: 24387991
    7. N-Methylaspartate induced nitric oxide synthase activation and nuclear factor-kB subunit p65 nuclear translocation in A549 cells were responsible for decreased CTP:phosphocholine cytidylyltransferase A expression PMID: 20661636
    8. Analyses showed genotype effects of PCYT1A genes on spina bifida risk, but did not show evidence of gene-nutrient. interactions. PMID: 17184542

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  • 相關疾?。?/div>
    Spondylometaphyseal dysplasia with cone-rod dystrophy (SMDCRD)
  • 亞細胞定位：
    Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Endoplasmic reticulum. Nucleus.
  • 蛋白家族：
    Cytidylyltransferase family
  • 組織特異性：
    Brain, placenta, liver, fetal and adult lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 8754

    OMIM: 123695

    KEGG: hsa:5130

    STRING: 9606.ENSP00000292823

    UniGene: Hs.135997