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STAG2 Recombinant Monoclonal Antibody

  • 中文名稱：
    STAG2重組抗體
  • 貨號(hào)：
    CSB-RA292183A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate
      All lanes: SA2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 142, 146 kDa
      Observed band size: 142 kDa
    • Immunofluorescence staining of MCF7 Cells with CSB-RA292183A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeated by 0.2% TritonX-100, and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4℃. Nuclear DNA was labeled in blue with DAPI. The secondary antibody was FITC-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA292183A0HU STAG2重組單克隆抗體是針對(duì)粘連蛋白復(fù)合體關(guān)鍵組分STAG2開發(fā)的高特異性科研工具。該抗體通過重組技術(shù)制備，可精準(zhǔn)識(shí)別內(nèi)源性STAG2蛋白，經(jīng)多平臺(tái)驗(yàn)證顯示其在ELISA、蛋白質(zhì)印跡（WB）和免疫熒光（IF）實(shí)驗(yàn)中均表現(xiàn)出優(yōu)異性能，推薦工作濃度為WB 1:500-1:5000、IF 1:20-1:200。STAG2作為染色體結(jié)構(gòu)維持的核心調(diào)控因子，參與染色質(zhì)三維構(gòu)象維持、姐妹染色單體粘連及轉(zhuǎn)錄調(diào)控，其功能異常與基因組不穩(wěn)定性及多種腫瘤發(fā)生密切相關(guān)。本產(chǎn)品適用于探究STAG2在細(xì)胞周期調(diào)控、DNA損傷修復(fù)機(jī)制中的分子作用，也可用于癌癥研究領(lǐng)域中染色體分離異常、表觀遺傳失調(diào)等病理過程的體外實(shí)驗(yàn)分析，為腫瘤生物學(xué)、發(fā)育生物學(xué)及表觀遺傳學(xué)等領(lǐng)域的基礎(chǔ)研究提供可靠檢測工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Cohesin subunit SA-2 (SCC3 homolog 2) (Stromal antigen 2), STAG2, SA2
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human SA2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    3H4
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
  • 基因功能參考文獻(xiàn)：
    1. STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. PMID: 29662124
    2. STAG2 loss of Expression is Associated with Cancer Progression in Upper Urinary Tract Carcinoma. PMID: 28967037
    3. these data suggest that STAG2 acts as a tumor suppressor gene in bladder cancer and may be a potential therapeutic target in bladder cancer PMID: 28627627
    4. Extending the lifespan of normal human cells due to inactivation of STAG2 could promote tumorigenesis by extending the period during which tumor-driving mutations occur. PMID: 28819029
    5. TAG2 is the most commonly mutated subunit, and in a recent analysis was identified as one of only 12 genes that are significantly mutated in four or more cancer types. PMID: 27207471
    6. the clinical features of these three cases are remarkably similar to those observed in other well-established cohesinopathies. Herein, we suggest that STAG2 is a dosage-sensitive gene and that heterozygous loss-of-function variants lead to a cohesinopathy. PMID: 28296084
    7. results indicated that the complete loss of STAG2 expression was predictive for better recurrence-free survival and cancer-specific survival, suggesting its potential value as a prognostic biomarker in bladder cancer PMID: 26838030
    8. We suggest that increased STAG2 gene copy number and dysregulation of its downstream target genes may be responsible for the specific clinical findings of this syndrome. PMID: 25677961
    9. Characterization of C-terminal nuclear localization signal of the human SA2 stromalin PMID: 25979289
    10. Data show a significantly higher stromal antigen 2 (STAG2) mRNA and protein levels in normal bladder cells than bladder cancer cells. PMID: 25867412
    11. Microduplication of chromosome Xq25 encompassing STAG2 gene in a boy with intellectual disability PMID: 25450604
    12. STAG2 promotes the correction of kMT attachment errors to ensure faithful chromosome segregation during mitosis. PMID: 25074805
    13. Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations PMID: 25223734
    14. Loss of STAG2 expression occurs in 15% of tumors and is associated with metastatic disease, suggesting a potential genetic vulnerability in Ewing sarcoma PMID: 25186949
    15. our study identifies the duplication of XIAP and STAG2 as the minimal duplicated region leading to the ID, facial morphological anomalies, and speech delay, specific to the patients with Xq25 duplication. PMID: 24733578
    16. In an independent EFT tissue microarray cohort, we show that STAG2 loss as detected by immunohistochemistry may be associated with more advanced disease (p = 0.15) and a modest decrease in overall survival (p = 0.10). PMID: 25010205
    17. Aneuploidy in human salivary gland carcinomas is not driven by loss of expression of STAG2. PMID: 24822266
    18. These data suggest that PARP is a potential target for tumors harboring inactivating mutations in STAG2, and strongly recommend that STAG2 status be determined and correlated with therapeutic response to PARP inhibitors PMID: 24356817
    19. Cross-sectional deep-sequencing analysis for clonal hierarchy demonstrated STAG2, SMC3, and RAD21 mutations to be ancestral in 18%, 18%, and 47% of cases, respectively, and each expanded to clonal dominance concordant with disease transformation PMID: 25006131
    20. Loss of STAG2 function is associated with non-invasive bladder cancer. PMID: 24270882
    21. Mutations in STAG2 is associated with acute myeloid leukemia. PMID: 24335498
    22. STAG2 is one of the most commonly mutated genes in bladder cancer. PMID: 24121789
    23. STAG2 is a new urothelial bladder cancer tumor suppressor acting through mechanisms that are different from its role in preventing aneuploidy. PMID: 24121791
    24. Inactivating point mutations in the STAG2 gene are not common in neuroblastoma tumors PMID: 24088605
    25. Somatic mutation of STAG2, an aneuploidy-related gene, is rare in acute leukemias. PMID: 22132872
    26. Low STAG2 expression and not mutation is associated with neoplasms. PMID: 22668012
    27. study has shown that diverse human cancers harbor mutations in the X-linked chromatid cohesion gene STAG2 and that these mutations cause aneuploidy PMID: 21852505
    28. evidence suggests STAG2 functions as a transcriptional co-activator by a mechanism involving protein-protein interactions with transcription factors PMID: 14660624
    29. Phosphorylation of SA2 is essential for cohesin dissociation during prophase and prometaphase, but is not required for cohesin cleavage by separase. PMID: 15737063
    30. Cohesion between sister chromatids is essential for their bi-orientation on mitotic spindles is mediated by a multisubunit complex called cohesin. PMID: 15737064

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
  • 蛋白家族：
    SCC3 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11355

    OMIM: 300826

    KEGG: hsa:10735

    STRING: 9606.ENSP00000218089

    UniGene: Hs.496710