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TACR1 Recombinant Monoclonal Antibody

  • 中文名稱：
    TACR1重組抗體
  • 貨號：
    CSB-RA555508A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: THP-1 whole cell lysate, Hela whole cell lysate, HepG2 whole cell lysate, MCF-7 whole cell lysate, Ntera-2 whole cell lysate, Mouse Brain whole cell lysate
      All lanes: TACR1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 47, 36 kDa
      Observed band size: 50 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA555508A0HU TACR1重組單克隆抗體是針對神經(jīng)激肽1受體（TACR1/NK1R）開發(fā)的高特異性檢測工具，該靶點為速激肽家族關(guān)鍵成員，廣泛分布于中樞及外周神經(jīng)系統(tǒng)，參與疼痛信號傳導、神經(jīng)源性炎癥和情緒調(diào)節(jié)等生理病理過程。本抗體經(jīng)ELISA和蛋白質(zhì)印跡（WB）嚴格驗證，在WB實驗中推薦使用1:500至1:5000的稀釋范圍，可特異性識別天然及重組TACR1蛋白，實驗數(shù)據(jù)顯示清晰的單一目標條帶且背景信號低，適用于檢測人類來源樣本。其應(yīng)用涵蓋神經(jīng)生物學研究領(lǐng)域，包括疼痛機制解析、焦慮/抑郁相關(guān)受體功能探索、神經(jīng)免疫交互作用研究，以及藥物靶點篩選中的受體表達水平分析。產(chǎn)品采用重組蛋白免疫策略制備，經(jīng)多步驟純化工藝確保高批間一致性，適用于細胞裂解液、組織勻漿等多種樣本類型，為研究TACR1介導的細胞信號通路及其在神經(jīng)系統(tǒng)疾病中的分子機制提供可靠工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1), TACR1, NK1R TAC1R
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    A synthesized peptide derived from human Neurokinin 1 Receptor
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1E5
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance P > substance K > neuromedin-K.
  • 基因功能參考文獻：
    1. The neuropeptide, substance P (SP), is the physiological ligand of the neurokinin-1 (NK-1) receptor that is consistently overexpressed in glioblastoma cells. The aim of this work was to study physico-chemical and biological properties of different SP analogues labeled with technetium-99m and lutetium-177 radionuclides. PMID: 30301182
    2. NK-1RA is recommended to use in carboplatin-based chemotherapy, not oxaliplatin-based chemotherapy PMID: 30019968
    3. Study revealed extensive distribution of SP and NK1R in nuclei intimately related to cardiorespiratory function and autonomic control, with significant co-distribution and co-localization with 5-HT in the medullary network in the normal human infant during development. A trend for NK1R binding to decrease with age was observed with significantly higher binding in premature and male infants. PMID: 29331576
    4. These results reveal a critical role for endosomal signaling of the NK1R in the complex pathophysiology of pain. PMID: 28566424
    5. The percentages of SP+ and NK1R+ expression populations of monocytes, helper T cells, natural killer T cells and basophils in peripheral blood of eczema patients were markedly elevated. PMID: 28154998
    6. Expression of NK1R increases in the eosinophils of chronic spontaneous urticaria (CSU) patients. Blockers of NK1R might be used for CSU treatment. PMID: 28871952
    7. NK-1R may positively regulate melanogenesis through Wnt/beta-catenin signaling pathway. PMID: 27835606
    8. This study revealed for the first time an increase of Mast Cells -nerve association and NK1R expression on Mast Cells during Allergic Rhinitis as well as nerve fibres containing receptors for mass cells. PMID: 28030866
    9. Kinase activation led to increased MMP-2 and MT1-MMP expression and melanoma cell migration induced by hHK-1. Thus, hHK-1 and the NK1 receptor are critical to melanoma cell migration and each may be a promising chemotherapeutic target PMID: 27458061
    10. Within a small cohort of patients who presented for treatment,a novel gene was identified that appears to contribute to anorexia nervosa pathophysiology, TACR1. PMID: 28291261
    11. NK1 receptor expression is increased in colonic tissues from experimental colitis models and in the colon of Irritable Bowel Disease patients. PMID: 28774868
    12. High Truncated Neurokinin-1 Receptor expression is associated with Neuroblastoma. PMID: 29061788
    13. Abnormalities in substance P neurokinin-1 receptor binding in key brainstem nuclei is associated with sudden infant death syndrome. PMID: 28931039
    14. TGF-beta1 down-regulates the gene expression of the full-length variant of NK-1 R in human keratocytes, which might impact its signaling pathway and thus explain the known delay in internalization after activation by SP seen with TGF-beta1 treatment. PMID: 26673553
    15. results suggest that ARRB1 plays an essential role in NK1R-mediated cell proliferation and G2/M transition in glioblastoma cells. Interference with ARRB1-mediated signaling via NK1R may have potential significance for therapeutic strategies targeting glioblastoma. PMID: 28341744
    16. up-regulated in nasal mucosa at contact point in intranasal mucosal contact point headache PMID: 26817501
    17. We showed that pretreating a cardiomyocyte cell line (H9C2) and a TNBC cell line (MDA-MB 231) with aprepitant, a SP receptor antagonist that is routinely used to treat chemotherapy-associated nausea, decreased DOX-induced reduction of viability, apoptotic cell death, and ROS production in cardiomyocytes PMID: 26981525
    18. These findings reveal important insight into the molecular mechanisms of the NK1R complex as a critical component in a model of pediatric liver cancer and may support the development of novel therapeutic interventions for hepatoblastoma PMID: 26516161
    19. Report absence of full-length neurokinin-1 receptor protein expression by cutaneous T cells in mycosis fungoides. PMID: 25783846
    20. Inhibition of CaV2.3 channels by NK1 receptors is sensitive to membrane cholesterol but insensitive to caveolin-1. PMID: 25204428
    21. NK-1 activation could enhance EGFR expression and phosphorylation, and then activate EGFR related Erk/MAPK and Akt pathway. PMID: 25817575
    22. The single nucleotide polymorphisms in the TACR1 gene are associated with sex differences in postoperative nausea and vomiting. PMID: 26012530
    23. Results show the existence of a relevant alteration in NK-1R expression in bipolar disorder patients and further suggest Substance P involvement in BD. PMID: 25841180
    24. Immunohistochemical NK-1R and pEGFR positivity with VDR negativity can be used to identify areas of sporadic colorectal neoplasia. PMID: 25684939
    25. Hepatoblastoma cells predominantly expressed the truncated splice variant of NK1R. PMID: 24412605
    26. Findings indicate a role of the TACR1 gene in the development of sicca syndrome in subjects affected with fibromyalgia. PMID: 25786041
    27. NK-1R activation by substance P stimulation promotes growth and migration of esophageal squamous cell carcinoma cells. PMID: 25659767
    28. Different NK1R subtype profiles of glomerular basement membrane (GBM) cell lines appear to influence the binding of SP conjugates and their cell internalization properties. PMID: 24552486
    29. Down-regulation of NK1R-Tr may be a key factor in maintaining the quiescent phenotype of breast cancer cells among bone marrow stroma. PMID: 25130457
    30. The association with TACR1 and bipolar affective disorder, alcohol dependence syndrome, and attention-deficit hyperactivity disorder suggests a shared molecular pathophysiology between these affective disorders. PMID: 24817687
    31. NK-1 receptors are expressed in uveal melanomas and uveal melanoma cell lines. PMID: 24548567
    32. TACR1 expression level was differentially altered in Crohn disease and ulcerative colitis patients. PMID: 23827863
    33. Residues 11-21 and residues 170-193 of NK1 receptor are binding sites for substance P. PMID: 24831006
    34. the primary function of betaARRs and ECE-1 in SP-dependent inflammatory signaling is to promote resensitization, which allows the sustained NK1R signaling from the plasma membrane that drives inflammation PMID: 24898255
    35. we demonstrated for the first time that the NK1R is expressed in human osteosarcoma cell line MG63 and that this receptor can be targeted with NK1R antagonists both in vitro as well as in vivo. PMID: 24190675
    36. data confirm the overall inflammatory nature of HIV-associated neuropathology, and a decrease in the expression of SP and NK1R-F. PMID: 23916293
    37. NK1 receptors may be activated, or up-regulated in the peripheral, painful tissue of a chronic pain condition. PMID: 24155873
    38. It seems that a common mechanism for cancer cell proliferation mediated by SP and the NK-1 receptor is triggered, as well as a common mechanism exerted by NK-1 receptor antagonists on tumor cells, i.e. apoptosis. PMID: 23933301
    39. Roles of full-length and truncated neurokinin-1 receptor on tumor progression and distant metastasis in human breast cancer. PMID: 23807418
    40. This suggests that potential pharmacological interventions that target NK-1R signaling may be most effective for treating distinct symptoms in IBD and IBS. PMID: 23582152
    41. High NK-1 Receptor expression is associated with breast cancer. PMID: 24030979
    42. NK1R forms physical complexes with NET. PMID: 23979140
    43. Each of the 5 single nucleotide polymorphism(SNP)s in the TACR1 gene is significantly related to alcohol dependence severity. PMID: 23078527
    44. Our results suggest that SP plays an important role in the development of pancreatic cancer metastasis and PNI, and blocking the SP/NK-1R signaling system is a novel strategy for the treatment of pancreatic cancer. PMID: 23345604
    45. NK1R expression is induced in ectopic endometrial tissue by peritoneal TNFalpha. PMID: 23553861
    46. NK1R expression correlates positively with plasma insulin, fatty acid, and complement C3 and negatively with adiponectin, CEBPalpha, CEBPbeta, and peroxisome proliferator-activated receptor-gamma mRNA expression in omental, but not subcutaneous, adipose tissue. PMID: 23257919
    47. PAR(2) has a higher apparent affinity for both beta-arrestins than does NK1R, recruits them at a faster rate, and exhibits more rapid desensitization of the G-protein signal. PMID: 23235155
    48. NK1R is a potential regulator of human glioma cell migration by the up-regulation of MMP-2 and MT1-MMP PMID: 23166329
    49. Neurokinin 1 receptor mediates membrane blebbing and sheer stress-induced microparticle formation in HEK293 cells PMID: 23024816
    50. investigation of age and sex influences on NK1 receptor expression in brain tissues PMID: 22225860

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11526

    OMIM: 162323

    KEGG: hsa:6869

    STRING: 9606.ENSP00000303522

    UniGene: Hs.633301