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TBR1 Recombinant Monoclonal Antibody

  • 中文名稱：
    TBR1重組抗體
  • 貨號：
    CSB-RA618090A0HU
  • 規(guī)格：
    ￥1320
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA618090A0HU TBR1重組單克隆抗體是通過重組蛋白免疫技術(shù)制備的高特異性抗體，靶向T-box腦轉(zhuǎn)錄因子1（TBR1）。該蛋白作為關(guān)鍵轉(zhuǎn)錄調(diào)控因子，參與大腦皮層神經(jīng)元的分化、突觸形成及神經(jīng)回路建立等過程，其功能異常與神經(jīng)發(fā)育障礙相關(guān)。本產(chǎn)品經(jīng)ELISA方法嚴格驗證，具備高親和力與特異性，能穩(wěn)定識別天然構(gòu)象的TBR1蛋白，不同批次間性能高度一致。適用于神經(jīng)發(fā)育機制研究、皮層神經(jīng)元分化模型驗證、自閉癥或癲癇等疾病相關(guān)信號通路分析等基礎(chǔ)科研領(lǐng)域。抗體采用無動物成分表達系統(tǒng)生產(chǎn)，避免交叉反應(yīng)風(fēng)險，可為神經(jīng)生物學(xué)研究提供可靠的實驗工具，尤其適用于體外蛋白互作分析及功能研究中的靶標定量檢測需求。
  • Uniprot No.：
  • 基因名：
    TBR1
  • 別名：
    T box brain 1 antibody; T box brain protein 1 antibody; T brain 1 protein antibody; T-box brain protein 1 antibody; T-brain-1 antibody; TBR 1 antibody; TBR-1 antibody; Tbr1 antibody; TBR1_HUMAN antibody; TES 56 antibody; TES-56 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human TBR1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    2E10
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons.
  • 基因功能參考文獻：
    1. TBR1 homodimerizes; it interacts with FOXP2, a transcription factor implicated in speech/language disorders, and this interaction is disrupted by pathogenic mutations affecting either protein PMID: 25232744
  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11590

    OMIM: 604616

    KEGG: hsa:10716

    STRING: 9606.ENSP00000374205

    UniGene: Hs.210862