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TOMM22 Recombinant Monoclonal Antibody

  • 中文名稱：
    TOMM22重組抗體
  • 貨號(hào)：
    CSB-RA277640A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: 293 whole cell lysate, Hela whole cell lysate, L02 whole cell lysate, HepF2 whole cell lysate, Raji whole cell lysate, Jurkat whole cell lysate, K562 whole cell lysate
      All lanes: TOMM22 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 16 kDa
      Observed band size: 18 kDa
    • IHC image of CSB-RA277640A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4℃ overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA277640A0HU TOMM22重組單克隆抗體是針對(duì)線粒體外膜轉(zhuǎn)位酶復(fù)合體22（TOMM22）靶點(diǎn)開(kāi)發(fā)的高特異性科研工具。該抗體識(shí)別的TOMM22蛋白是線粒體外膜轉(zhuǎn)位酶（TOM）復(fù)合物的核心組分，在介導(dǎo)核編碼蛋白跨線粒體膜運(yùn)輸過(guò)程中起關(guān)鍵作用，其功能異常與細(xì)胞能量代謝失調(diào)及程序性死亡調(diào)控密切相關(guān)。經(jīng)嚴(yán)格驗(yàn)證，本產(chǎn)品在Western Blot實(shí)驗(yàn)中可檢測(cè)到單一清晰目標(biāo)條帶，免疫組化實(shí)驗(yàn)顯示其在線粒體膜結(jié)構(gòu)的特異性定位，推薦使用稀釋度為WB 1:500-1:5000、IHC 1:50-1:200，同時(shí)在ELISA平臺(tái)中展現(xiàn)優(yōu)異抗原結(jié)合能力。適用于研究線粒體蛋白質(zhì)轉(zhuǎn)運(yùn)機(jī)制、細(xì)胞能量代謝動(dòng)態(tài)平衡及凋亡信號(hào)通路調(diào)控等基礎(chǔ)生命科學(xué)領(lǐng)域，可為線粒體相關(guān)疾病模型的分子機(jī)制探索、藥物靶點(diǎn)篩選提供可靠檢測(cè)支持。該重組單克隆抗體具有批次穩(wěn)定性高、交叉反應(yīng)性低的特點(diǎn)，滿足細(xì)胞生物學(xué)、分子病理學(xué)等研究中對(duì)線粒體功能檢測(cè)的技術(shù)需求。
  • Uniprot No.：
  • 基因名：
    TOMM22
  • 別名：
    Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog), TOMM22, TOM22
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human TOMM22
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    7C11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore. Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases.
  • 基因功能參考文獻(xiàn)：
    1. A directed proteomic approach discovered the novel interaction of BKCa with Tom22, a component of the mitochondrion outer membrane import system, and the adenine nucleotide translocator (ANT). PMID: 27592226
    2. Tom22 is essential for metabolic conversion, as its knockdown by small interfering RNA (siRNA) completely ablated progesterone conversion in both steroidogenic mouse Leydig MA-10 and human adrenal NCI cells. PMID: 26787839
    3. Blockade of mitochondrial protein import triggers the recruitment of PARK2, by PINK1, to the TOMM machinery. PMID: 24149440
    4. Studies indicate that PUMA and TOMM22 as potential targets for miRNA-BART viral transcripts. PMID: 22178394
    5. The interaction with the cytosolic domain of Tom22 helps Bax to acquire a conformation able to interact with the outer mitochondrial membrane. PMID: 22198199
    6. the cytosolic domains of Tom20 and Tom22 function to maintain their substrate preproteins unfolded and prevent them from aggregating on the mitochondrial surface PMID: 14699115
    7. We have identified TOM22, a component of the translocase of the outer mitochondrial membrane (TOM), as a mitochondrial receptor of Bax. PMID: 17096026

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  • 亞細(xì)胞定位：
    Mitochondrion outer membrane; Single-pass membrane protein.
  • 蛋白家族：
    Tom22 family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18002

    OMIM: 607046

    KEGG: hsa:56993

    STRING: 9606.ENSP00000216034

    UniGene: Hs.595072