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UAP1 Recombinant Monoclonal Antibody

  • 中文名稱：
    UAP1重組抗體
  • 貨號：
    CSB-RA174034A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate
      All lanes: UAP1 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 59, 58, 59 kDa
      Observed band size: 59 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA174034A0HU UAP1重組單克隆抗體是經(jīng)嚴格驗證的高特異性科研工具，適用于ELISA和Western Blot實驗，其中WB推薦使用1:500-1:5000的稀釋范圍。該抗體靶向UAP1蛋白，該蛋白作為尿苷二磷酸-N-乙酰葡糖胺焦磷酸化酶，負責催化糖核苷酸合成，在蛋白質(zhì)糖基化修飾和細胞外基質(zhì)形成中起關(guān)鍵作用，其異常表達與腫瘤發(fā)生及糖代謝紊亂密切相關(guān)。經(jīng)實驗驗證，該抗體在多種細胞裂解液中均能有效識別目標蛋白，呈現(xiàn)單一清晰條帶，且在低濃度樣本中仍保持高靈敏度，背景信號顯著低于同類產(chǎn)品。ELISA應(yīng)用中表現(xiàn)出優(yōu)異的線性檢測范圍和批次間穩(wěn)定性，滿足定量分析的實驗需求。本產(chǎn)品適用于探究UAP1在糖基化通路調(diào)控、腫瘤細胞異常增殖機制以及代謝性疾病模型中的分子作用，可配合細胞轉(zhuǎn)染、蛋白互作等實驗方案，為糖生物學研究和疾病相關(guān)分子機制探索提供可靠檢測工具。
  • Uniprot No.：
  • 基因名：
    UAP1
  • 別名：
    UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1), UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)], UAP1, SPAG2
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human UAP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    1F2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
  • 基因功能參考文獻：
    1. Results identified an enzyme, UAP1, which is highly overexpressed in prostate cancer and protects cancer cells from endoplasmic reticulum stress conferring a growth advantage. PMID: 25241896
  • 亞細胞定位：
    Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.
  • 蛋白家族：
    UDPGP type 1 family
  • 組織特異性：
    Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 12457

    OMIM: 602862

    KEGG: hsa:6675

    STRING: 9606.ENSP00000356903

    UniGene: Hs.492859