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  4. Recombinant Arabidopsis thaliana LRR receptor-like serine/threonine-protein kinase FLS2 (FLS2), partial

Recombinant Arabidopsis thaliana LRR receptor-like serine/threonine-protein kinase FLS2 (FLS2), partial

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  • 中文名稱：
    Recombinant Arabidopsis thaliana LRR receptor-like serine/threonine-protein kinase FLS2 (FLS2), partial
  • 貨號(hào)：
    CSB-EP880781DOA
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
    FLS2
  • Uniprot No.：
  • 別名：
    Protein FLAGELLIN-SENSING 2;Protein FLAGELLIN-SENSITIVE 2
  • 種屬：
    Arabidopsis thaliana (Mouse-ear cress)
  • 蛋白長(zhǎng)度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    45.5 kDa
  • 表達(dá)區(qū)域：
    828-1173aa
  • 氨基酸序列
    LTCCKKKEKKIENSSESSLPDLDSALKLKRFEPKELEQATDSFNSANIIGSSSLSTVYKGQLEDGTVIAVKVLNLKEFSAESDKWFYTEAKTLSQLKHRNLVKILGFAWESGKTKALVLPFMENGNLEDTIHGSAAPIGSLLEKIDLCVHIASGIDYLHSGYGFPIVHCDLKPANILLDSDRVAHVSDFGTARILGFREDGSTTASTSAFEGTIGYLAPEFAYMRKVTTKADVFSFGIIMMELMTKQRPTSLNDEDSQDMTLRQLVEKSIGNGRKGMVRVLDMELGDSIVSLKQEEAIEDFLKLCLFCTSSRPEDRPDMNEILTHLMKLRGKANSFREDRNEDREV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    C-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Constitutes the pattern-recognition receptor (PPR) that determines the specific perception of flagellin (flg22), a potent elicitor of the defense response to pathogen-associated molecular patterns (PAMPs). Flagellin-binding to the receptor is the first step to initiate the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6), resulting in enhanced resistance against pathogens. Binding to the effector AvrPto1 or to the phosphatase hopD2 from Pseudomonas syringae blocks the downstream plant immune response.
  • 基因功能參考文獻(xiàn)：
    1. LLG1 constitutively associates with the PAMP receptor FLAGELLIN SENSING 2 (FLS2) and the elongation factor-Tu receptor, and forms a complex with BRASSINOSTEROID INSENSITIVE 1-ASSOCIATED RECEPTOR KINASE 1 in a ligand-dependent manner, indicating that LLG1 functions as a key component of PAMP-recognition immune complexes PMID: 28507137
    2. Combination of two identified mutations into a single allele further increased FLS2-mediated responses to the Erwinia amylovora flagellin peptide in Arabidopsis. PMID: 27270917
    3. The study demonstrates that the G proteins are directly coupled to the FLS2 receptor complex and regulate immune signaling through both pre-activation and post-activation mechanisms. PMID: 27043937
    4. MKKK7 negatively regulates FLS2 signaling and basal immunity. PMID: 26769563
    5. We found that all tested variants of AVR3a suppress defense responses triggered by flg22 and reduce internalization of activated FLS2. Moreover, we discovered that AVR3a associates with the Dynamin-Related Protein 2 (DRP2) PMID: 26348328
    6. each investigated root tissue is able to perceive flg22 if FLS2 is present and that tissue identity is a major element of microbe-associated molecular patterns (MAMPs)perception in roots. PMID: 25627577
    7. A tissue- and cell type-specific map of FLS2 expression has been created correlating with prominent entry sites and target tissues of plant bacterial pathogens. PMID: 25205577
    8. Functionally redundant RXLR effectors from Phytophthora infestans act at different steps to suppress early flg22-triggered immunity. PMID: 24763622
    9. FLS2 complexes regulate the expression of AtCLCd, further supporting a role for AtCLCd in pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI). PMID: 24449384
    10. Degradation of FLS2 plays a role in desensitizing Arabidopsis cells to bacterial flagellin or flg22 peptide. PMID: 24220680
    11. Our findings identify that VPS37-1, and likewise VPS28-2, regulate late FLS2 endosomal sorting and reveals that ESCRT-I is critical for flg22-activated stomatal defenses involved in plant immunity PMID: 24385929
    12. FLS2-BIK1 dissociation and FLS2-BAK1 association are not sufficient for FLS2-mediated defense activation, but the proposed FLS2 phosphorylation site Ser-938 and FLS2 kinase activity are needed for overall defense activation and for appropriate flg22-stimulated phosphorylation of BIK1 and homologs PMID: 23637603
    13. The structural mechanism of the FLS2-flg22 interaction and subsequent receptor-mediated signalling. [Review] PMID: 23053766
    14. these data reveals the molecular mechanisms underlying FLS2-BAK1 complex recognition of flg22 and provide insight into the immune receptor complex activation. PMID: 24114786
    15. FLS2 localizes to bona fide endosomes via two distinct endocytic trafficking routes depending on its activation status. PMID: 23085733
    16. FLS2 does not recognize CLV3 and that the shoot apical meristem is immune to bacteria independently of CLV3 perception. PMID: 22923673
    17. The results indicate that ligand perception in FLS2 is a complex molecular process that involves LRRs from both the outermost and innermost LRRs of the FLS2 ectodomain. PMID: 22634763
    18. FLS2 triggered activation of pathogenesis-related genes in Arabidopsis. PMID: 22080602
    19. FLS2 is a PRR, which recognizes a part of bacterial flagellin. FLS2 forms a PTI signalling complex, some components of which are guarded by R proteins. PMID: 21726371
    20. FLS2 functions beyond flagellin perception to detect other microbe-associated molecular patterns PMID: 21576467
    21. Flagellin Sensitive2 (FLS2) accumulation was reduced in etr1 and ein2, indicating a requirement of ethylene signaling for FLS2 expression. PMID: 20592040
    22. These results suggest a particularly important role of FLS2-mediated resistance to coronatine-deficient mutant Pst DC3000 bacteria. PMID: 20457804
    23. FLS2 tolerated mild underglycosylation occurring in stt3a but was sensitive to severe underglycosylation induced by tunicamycin treatment PMID: 20007973
    24. these results show that FLS2 constitutes the pattern-recognition receptor that determines the specificity of flagellin perception. PMID: 16377758
    25. Species-specific differences in flagellin perception abilities to identify LeFLS2 as the flagellin receptor in Ararbidopsis. PMID: 17530419
    26. Data suggest that the reduced mobility of FLS2 after binding flg22 and its existence in monomeric form are important mechanistic features of FLS2 early signaling. PMID: 17925310
    27. we propose that both domains of Pseudomonas syringae pv tomato DC3000 AvrPtoB act together to support the virulence of PtoDC3000 in Arabidopsis through their ability to eliminate FLS2 from the cell periphery. PMID: 19062288

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 組織特異性：
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接：

    KEGG: ath:AT5G46330

    STRING: 3702.AT5G46330.1

    UniGene: At.29960