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  4. Recombinant Drosophila melanogaster Chromosomal serine/threonine-protein kinase JIL-1 (JIL-1), partial

Recombinant Drosophila melanogaster Chromosomal serine/threonine-protein kinase JIL-1 (JIL-1), partial

  • 中文名稱：
    黑腹果蠅JIL-1重組蛋白
  • 貨號(hào)：
    CSB-YP893223DLU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅JIL-1重組蛋白
  • 貨號(hào)：
    CSB-EP893223DLU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅JIL-1重組蛋白
  • 貨號(hào)：
    CSB-EP893223DLU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅JIL-1重組蛋白
  • 貨號(hào)：
    CSB-BP893223DLU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅JIL-1重組蛋白
  • 貨號(hào)：
    CSB-MP893223DLU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    JIL-1
  • Uniprot No.：
  • 別名：
    JIL-1; CG6297; Chromosomal serine/threonine-protein kinase JIL-1; EC 2.7.11.1
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Phosphorylates 'Ser-10' of histone H3. May regulate gene expression by establishing or maintaining the structure of more open chromatin regions. Also required for normal polytene chromosome structure, for oogenesis and for viability throughout development. Regulates the structure of polytene chromosomes in salivary glands. May phosphorylate 'Ser-1' of histone H2A.
  • 基因功能參考文獻(xiàn)：
    1. our data indicate that the conserved H3S28 residue in metazoans has a role in supporting PRC2 catalysis. PMID: 26004180
    2. results strongly suggest that the action of JIL-1 depends on which telomere domain, which chromosome and which promoter is embedded in the telomere chromatin. PMID: 24244743
    3. JIL-1 regulated heterochromatin in the context of the chromocenter and fourth chromosome by creating a composite H3S10phK9me2 mark together with the Su(var)3-9 methyltransferase. PMID: 24429699
    4. Enrichment of JIL-1 and the H3S10ph mark are predominantly associated with active genes in Drosophila. PMID: 24598257
    5. The results suggest that JIL-1 is not a histone H3S28 kinase and that it is not involved in 14-3-3 recruitment in Drosophila. PMID: 23638096
    6. epigenetic H3S10 phosphorylation mark itself functions as a causative regulator of chromatin structure independently of any structural contributions from the JIL-1 protein. PMID: 23723094
    7. JIL-1 and Z4 (also known as Putzig), which are necessary for establishing a fine-tuned regulation of the transcription of the major component of Drosophila telomeres, the HeT-A retrotransposon, thus guaranteeing genome stability PMID: 23271984
    8. JIL-1 and phosphoacetylated H3 histone are found at enhancers genome-wide prior to activation of transcription PMID: 22508764
    9. JIL-1 loss-of-function alleles can act either as an enhancer or indirectly as a suppressor of w(m4) position-effect variegation depending on the precise levels of JIL-1 kinase activity. PMID: 22634714
    10. Structural contributions from the JIL-1 protein are unlikely to play a role in counteracting heterochromatic spreading and gene silencing in position-effect variegation. PMID: 22247192
    11. A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila. PMID: 21515582
    12. JIL-1 participates in a complex histone modification network that characterises active, decondensed chromatin PMID: 21423663
    13. Data show that in the absence of JIL-1 kinase activity, Su(var)3-7 gets redistributed and upregulated on the chromosome arms. PMID: 20457875
    14. interaction with a developmentally regulated splice variant from the complex lola locus encoding multiple different zinc finger domain proteins PMID: 12538650
    15. JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression PMID: 14668387
    16. The JIL-1 kinase regulates the structure of Drosophila polytene chromosomes. PMID: 15986206
    17. JIL-1 kinase is required to maintain nuclear morphology and integrity of nurse cells during oogenesis; this function may be linked to molecular interactions with lamin Dm0. PMID: 16254246
    18. Proper dosage compensation of eye pigment levels in males controlled by X-linked white alleles requires normal JIL-1 function. PMID: 16307450
    19. JIL-1 functions in vivo in a pathway that includes Su(var)3-9, which is a major catalyst for dimethylation of the histone H3K9 residue, HP1 recruitment, and the formation of silenced heterochromatin. PMID: 16339185
    20. JIL-1 and Chromator interact in an interband-specific complex that functions to establish or maintain polytene chromosome structure in Drosophila. PMID: 16723739
    21. The gain of function allele is a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing. PMID: 17435241
    22. that a reduced level of histone H4 acetylated at Lys12 by ATAC attenuates histone H3 phosphorylation at Ser10 by JIL-1 owing to reduced binding of JIL-1 to hypoacetylated chromatin. PMID: 18796537
    23. the COOH-terminal domain of the JIL-1 histone H3S10 kinase interacts with histone H3 and is required for correct targeting to chromatin PMID: 18819909

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  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Note=Associates with chromosomes throughout the cell cycle. Localizes to interband regions along the polytene chromosomes and is enriched almost two-fold on the male X chromosome compared to the autosome.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family
  • 數(shù)據(jù)庫(kù)鏈接：

    KEGG: dme:Dmel_CG6297

    STRING: 7227.FBpp0304953

    UniGene: Dm.3098