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  4. Recombinant Drosophila melanogaster DE-cadherin (shg), partial

Recombinant Drosophila melanogaster DE-cadherin (shg), partial

  • 中文名稱：
    黑腹果蠅shg重組蛋白
  • 貨號(hào)：
    CSB-YP637588DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅shg重組蛋白
  • 貨號(hào)：
    CSB-EP637588DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅shg重組蛋白
  • 貨號(hào)：
    CSB-EP637588DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅shg重組蛋白
  • 貨號(hào)：
    CSB-BP637588DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅shg重組蛋白
  • 貨號(hào)：
    CSB-MP637588DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    shg
  • Uniprot No.：
  • 別名：
    shg; E-cadherin; CG3722; DE-cadherin; Protein shotgun
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cadherins are calcium-dependent cell adhesion proteins. In connecting cells they preferentially interact with themselves in a homophilic manner; cadherins may thus contribute to the sorting of heterogeneous cell types. During oogenesis, integral component of the guidance mechanisms that regulate the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Functions downstream of the two chemoattractant receptors, Pvr and Egfr, to promote BC adhesion between the leader cells of the migrating cluster and the surrounding nurse cells. This adhesion increases Rac1 signaling in the leading cells, which in turn stabilizes DE-cadherin/DE-cadherin adhesions through the formation of forward-directed protrusions which attach/detach to the surrounding nurse cells in order to pull the cluster through the egg chamber to the oocyte. Within the BC cluster, also promotes adhesion between BCs, and between BCs and polar cells which enables the lead BC to communicate direction to the other cells in the cluster, providing polarity to each individual cell and ensuring collective behavior. May function in cell intercalation in the lateral epidermis during germband extension. Contributes to the determination of body left-right asymmetry by enhancing Myo31DF activity and inhibiting Myo61F activity.
  • 基因功能參考文獻(xiàn)：
    1. In disc-proper epithelial cells, DE-cadherin localizes to the zonula adherens, and in puncta at the basal, and lateral sides. Fra overexpression of affects DE-Cadherin distribution and apico-basal cell shape so that there is loss of DE-Cadherin in the basal and lateral regions. PMID: 29518139
    2. several phospho-mutations dramatically reduced the biosynthetic turnover rate of DE-Cad during apical-basal polarization. PMID: 28219947
    3. Transmission of cytokinesis forces via E-cadherin dilution and actomyosin flows PMID: 28296858
    4. alpha-Catenin controls actomyosin dynamics by stabilising and promoting the formation of actomyosin foci, and also stabilises DE-Cadherin (Drosophila E-Cadherin, also known as Shotgun) at the cell membrane, suggesting that medioapical actomyosin contractility regulates junction stability. PMID: 27831494
    5. In embryos mutant for the FGF signaling pathway components Branchless and Breathless, zygotic E-cadherin is not targeted to adherens junctions, causing midgut pocket collapse. PMID: 26604222
    6. These results indicate an active role for E-Cad in mediating cohesive and ordered migration of non-epithelial cells, and discount the notion of E-Cad as just an epithelial feature that has to be switched off to enable migration of mesenchymal cells. PMID: 26272476
    7. the sustained E-cadherin-dependent adhesion organizes the microvilli meshwork and ensures the proper attachment of RCs to the PM, thereby counteracting the increasing membrane tension induced by exponential tissue growth. PMID: 26424451
    8. Hox coordination of tissue morphogenesis relies on boundary fold formation through the modulation of DE-cad positioning PMID: 26206615
    9. The membrane-proximal half of the DE-cadherin extracellular region is dispensable for many developmental events,but it is essential for efficient and robust apical constriction during ventral furrow formation. PMID: 20184661
    10. E-cadherin cluster organization in Drosophila embryos.Dynamin-dependent endocytosis targets large clusters of E-cadherin. PMID: 24184100
    11. E-cadherin promotes in vivo cell movement by multiple mechanisms, the combination of which orchestrates collective direction sensing. Of particular note, E-cadherin functions at the leading edge in a positive feedback loop with the small GTPase Rac as an integral part of the direction-sensing mechanism. PMID: 24855950
    12. E-cadherin is required to maintain Drosophila prohemocyte multipotency and block differentiation. PMID: 24040319
    13. findings show that planar polarization of flows emerges from polarized fluctuations in the levels of E-cadherin clusters that produce transient and oscillating asymmetries of coupling; these fluctuations are triggered by polarized E-cadherin endocytosis and are amplified by flow itself PMID: 23871590
    14. loss of DE-cadherin strongly enhances the raw mutant gonad phenotype, while increasing DE-cadherin function rescues this phenotype PMID: 22575490
    15. findings suggest that Hrp38 and its association with poly(ADP-ribose) control germline stem cell self-renewal and oocyte localization by regulating DE-cadherin translation PMID: 22453833
    16. DE-Cad and armadillo in adherens junctions of polarizing epithelial cells had much faster biosynthetic turnover than in polarized cells. PMID: 22159415
    17. Cno function as a novel regulator of neuron-glia interactions, forming a complex with Shg, Wrapper and Neurexin IV. PMID: 21389054
    18. Jafrac1-mediated reduction of hydrogen peroxide is required to maintain DE-cadherin protein levels in the early embryo. PMID: 21316590
    19. The studies demonstrate a novel and crucial role for Pak1 and E-cadherin endocytosis in determining salivary gland lumen size and shape, and also identify a mechanism for multiple lumen formation. PMID: 21068057
    20. E-cadherin orchestrates multiple aspects of stem cell behavior PMID: 20824213
    21. regulates orientation of asymmetric cell division in the sensory organ lineage PMID: 11818059
    22. study demonstrates that anchorage of germline stem cells (GSCs) in their niche by DE-cadherin-mediated adhesion is important for stem cell maintenance and function. PMID: 12052957
    23. functions in normal optic placode morphogenesis PMID: 12163402
    24. mediates cell adhesion and is essential for maintaining somatic stem cells in the Drosophila ovary PMID: 12393817
    25. DE-cadherin plays a pivotal role in larval brain proliferation, brain cortex morphogenesis, and axon growth PMID: 12716940
    26. Data show that Drosophila E-cadherin is essential both for germ cell ensheathment and gonad compaction, and is upregulated in the somatic gonad at the time of gonad formation. PMID: 12900457
    27. DE-cadherin plays a pivotal role in delamination and polarized division of neuroblasts. PMID: 15183719
    28. Elevated transcription of DE-cadherin is sufficient to attract the oocyte to lateral and anterior positions. PMID: 15852002
    29. Results describe the requirements for Drosophila melanogaster epithelial (DE) cadherin regulation in vivo. PMID: 16129787
    30. regulation of cadherin-based adherens junctions by Rac is critical for salivary gland morphogenesis and that this regulation occurs through dynamin-mediated endocytosis PMID: 16412417
    31. zinc is a crucial regulator of developmental processes and can affect DE-cadherin expression on multiple levels PMID: 16481356
    32. DE-cadherins integrate input from at least two signaling pathways, resulting in a coordinated cell movement PMID: 16887833
    33. While Decapentaplegic (Dpp) acts downstream of Ras to maintain vein cell identity in the pupal wing, these results indicate that Ras controls Shg localization via a Dpp-independent mechanism. PMID: 17888420
    34. Uncoupling stability and mobility of E-cadherin complexes suggests that stable epithelia may remodel through the regulated mobility of very stable adhesive foci. PMID: 18480755
    35. levels of E-cadherin, an adherens junction component and Rab11-compartment cargo, are dynamically regulated by trafficking during tracheal development PMID: 18641639
    36. Overexpressed Armadillo mutants exhibit different levels of activity and stability, but retain E-Cadherin binding. PMID: 18682750
    37. Demonstrate that E-cadherin (E-cad) is required for stable attachment between the an intestinal stem cell and a progenitor cell. PMID: 19021776

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    In early stage 9 and stage 10 oocytes, expressed in border cells, strongly expressed in polar cells and very weakly expressed in the nurse cells (at protein level). In the embryo, expressed in the leading edge cells of the dorsal epidermis (at protein lev
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