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  4. Recombinant Drosophila melanogaster Lysine-specific demethylase lid (lid), partial

Recombinant Drosophila melanogaster Lysine-specific demethylase lid (lid), partial

  • 中文名稱：
    黑腹果蠅lid重組蛋白
  • 貨號：
    CSB-YP895166DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅lid重組蛋白
  • 貨號：
    CSB-EP895166DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅lid重組蛋白
  • 貨號：
    CSB-EP895166DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅lid重組蛋白
  • 貨號：
    CSB-BP895166DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅lid重組蛋白
  • 貨號：
    CSB-MP895166DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    lid
  • Uniprot No.：
  • 別名：
    lid; CG9088; Lysine-specific demethylase lid; EC 1.14.11.-; Histone demethylase lid; Jumonji/ARID domain-containing protein lid; Protein little imaginal disks; Retinoblastoma-binding protein 2 homolog
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. Regulates the expression of clock-controlled genes including tim, per and cry.
  • 基因功能參考文獻：
    1. However, for the N terminal region harboring both a PHD and an ARID finger, Lid anchors to the NuMat via both protein-protein and protein-DNA interactions. The association of JmjC domain with NuMat is the first report of the association of a demethylase domain with NuMat suggesting that Lid, a demethylase, being part of NuMat might be involved in regulating the chromatin dynamics via its NuMat association. PMID: 30207309
    2. Analyses reveal KDM5 as a key regulator of larval growth and offer an invaluable tool for defining the biological activities of KDM5 family proteins. PMID: 29764901
    3. Therefore Kdm5/Lid controls chromatin architecture in meiotic prophase I oocytes independently of its demethylase activity. PMID: 27494704
    4. we demonstrate a direct, critical role for KDM5 in the activation of genes required for the integrity and functioning of mitochondria PMID: 26673323
    5. KDM5 interacts with Foxo to modulate cellular levels of oxidative stress.KDM5 interacts with the lysine deacetylase HDAC4 to promote Foxo deacetylation, which affects Foxo DNA binding. PMID: 25329053
    6. dKDM5/LID regulates Drosophila hematopoietic development PMID: 26183107
    7. The results indicate that, at developmental genes, dKDM5/LID and ASH2 coordinately regulate H3K4me3 at the transcription-start site and that this dynamic regulation contributes to transcription. PMID: 22904080
    8. These findings highlight the importance of Lid function in the regulated removal and recognition of histone H3 lysine 4 during development. PMID: 21124823
    9. Lid knockdown using RNA interference results in a specific genome-wide increase in histone lysine methylation levels without affecting other patterns of H3 methylation, and results in an altered distribution of the chromo-helicase protein Chd1. PMID: 17351630
    10. Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate histone H3trimethyl-Lys4. PMID: 17351631
    11. The finding that Lid antagonizes Rpd3 function provides an explanation for the genetic classification of Lid as a positive transcription regulator. PMID: 19114561

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    JARID1 histone demethylase family
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG9088

    STRING: 7227.FBpp0297914

    UniGene: Dm.2779