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  4. Recombinant Drosophila melanogaster Probable RNA-binding protein orb2 (orb2), partial

Recombinant Drosophila melanogaster Probable RNA-binding protein orb2 (orb2), partial

  • 中文名稱：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-YP893322DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-EP893322DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-EP893322DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-BP893322DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅orb2重組蛋白
  • 貨號(hào)：
    CSB-MP893322DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    orb2
  • Uniprot No.：
  • 別名：
    orb2; CG43782; Translational regulator orb2
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    RNA-binding protein involved in translational regulation and required for long-term memory. Required in mushroom body gamma neurons for long-term memory in male courtship. Binds to mRNA 3'-UTRs. In its monomeric form, acts as a translational repressor of genes involved in neuronal growth, synapse formation and protein turnover. In its amyloid-like oligomeric form, acts as a translational activator. The monomeric form reduces poly(A) tail length and destabilizes mRNA while the oligomeric form protects and elongates the poly(A) tail and stabilizes mRNA. Involved in asymmetric cell division in the central nervous system. Plays a role in synapse formation and morphology at neuromuscular junctions by modulating the translation of the tumor suppressor brat. Required for the progression of spermatogenesis through meiosis and for sperm differentiation. During sperm differentiation, required to asymmetrically localize and activate the translation of protein kinase aPKC mRNAs which is necessary for spermatid cyst polarization. Also required during spermatid cyst polarization for localization and translation of its own mRNA.; Required for initial memory acquisition. Following subsequent late dopaminergic pathway activation, recruits isoform B into a complex to activate translation of CaMKII which is required for long-term memory consolidation.
  • 基因功能參考文獻(xiàn)：
    1. We present here evidences of a novel genetic mechanism to regulate synapse fine tuning during development and propose an equilibrium between Orb2 conformational state and nervous system formation. PMID: 29105522
    2. The N-terminus of Orb2A not only promotes the formation of fibrils, but also forms the fibril core. PMID: 27922050
    3. Data confirm the original hypothesis that the glutamine, histidine-rich (Q/H-rich) domain of Orb2 can bind to transition metals via its His residues. Hence, the Q/H rich domain behaves like other H-rich domains, most of which were shown to be metal binding domains. PMID: 28763009
    4. Study showed that the N-terminus specific to Orb2A can bind to lipid membranes; binding occurs preferentially to curved membranes and requires the membranes to be negatively charged. When binding to lipid membranes, the N-terminus of Orb2A undergoes a transition from a dynamic, intrinsically disordered state to a less dynamic alpha-helix. This lipid membrane interaction can prevent the N-terminus from forming amyloid f... PMID: 28700922
    5. Authors posit that pasilla-mediated processing of unspliced Orb2A mRNA integrates experience and internal state to control Orb2A protein abundance and long-term memory formation. PMID: 28525754
    6. rapidly forms amyloids and its toxic intermediates are extremely transient PMID: 26812143
    7. Data support a model in which monomeric Orb2 keeps target mRNA in a translationally dormant state and experience-dependent conversion to the amyloidogenic state activates translation, resulting in persistent alteration of synaptic activity and stabilization of memory. PMID: 26638074
    8. we present evidence that, during learning, the translational regulator Orb2A tags specific synapses of mushroom body neurons for later consolidation. Consolidation involves the subsequent recruitment of Orb2B and the activity-dependent synthesis of CaMKII PMID: 26095367
    9. analysis of a partial loss of function orb2 mutant suggests that the orb2 differentiation phenotypes are independent of the earlier arrest in meiosis PMID: 23209437
    10. This study demonistrated that Drosophila CPEB Orb2A mediates memory independent of Its RNA-binding domain. PMID: 23083740

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  • 亞細(xì)胞定位：
    Perikaryon. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Cytoplasm. Cytoplasm, perinuclear region.; [Isoform A]: Cell junction, synapse.; [Isoform B]: Perikaryon. Cell projection, axon. Cell junction, synapse.
  • 組織特異性：
    Broadly expressed throughout the nervous system of embryo, larva and adult including the ventral nerve cord and brain (at protein level). In early embryos, deposited maternally and distributed uniformly throughout the embryo until the extended germband st
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG43782

    STRING: 7227.FBpp0303905

    UniGene: Dm.4024