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  4. Recombinant Drosophila melanogaster Protein cup (cup), partial

Recombinant Drosophila melanogaster Protein cup (cup), partial

  • 中文名稱：
    Recombinant Drosophila melanogaster Protein cup(cup) ,partial
  • 貨號：
    CSB-YP895165DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Protein cup(cup) ,partial
  • 貨號：
    CSB-EP895165DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Protein cup(cup) ,partial
  • 貨號：
    CSB-EP895165DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Protein cup(cup) ,partial
  • 貨號：
    CSB-BP895165DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Drosophila melanogaster Protein cup(cup) ,partial
  • 貨號：
    CSB-MP895165DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    cup
  • Uniprot No.：
  • 別名：
    cup; fs(2)cup; CG11181; Protein cup; Oskar ribonucleoprotein complex 147 kDa subunit
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Adapter protein that plays a central role in localization of transcripts in the oocyte and in young embryos. Maintains RNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation. Binds to and recruits eIF-4E to the 3'-UTR of some mRNA targets which prevents interaction between eIF4E1 and eIF4G. This may contribute to translational repression but does not appear to be necessary for it to occur. Can promote translational repression independently of deadenylation and eIF4E1 binding. Required for correct localization of eIF4E1 in the developing oocyte. Required for translational repression of oskar (osk) mRNA. Also required for the translational repression of nanos (nos) mRNA. Promotes the accumulation of the germ plasm components osk, vas and stau at the posterior pole of the oocyte and is required for germ cell development. Represses orb positive autoregulatory activity which prevents premature activation of orb and ensures its accumulation specifically in the developing oocyte. In 0-1 hour embryos, forms a complex with me31B, cup, tral and pAbp which binds to various mRNAs including maternal mRNAs, and downregulates their expression during the maternal-to-zygotic transition.
  • 基因功能參考文獻：
    1. loss of cup disrupts the localization of both the oskar mRNA and its associated proteins to the posterior pole of the developing oocyte. PMID: 27554167
    2. cup mutants have increased numbers of satellite boutons and EPSP. cup genetically interacts with EndoA and Dap160. PMID: 26102195
    3. Cup promotes the accumulation of the germ plasm determinants at the posterior pole of the oocyte. PMID: 22454519
    4. The structure provides insight into the mechanism by which Cup disrupts eIF4E-eIF4G interaction and has broader implications for understanding the role of 4E-BPs in translational regulation. PMID: 22832024
    5. Cup blocks the precocious activation of the orb autoregulatory loop PMID: 22164257
    6. n addition to inducing translational repression, CUP maintains mRNA targets in a repressed state by promoting their deadenylation and protects deadenylated mRNAs from further degradation PMID: 21937713
    7. Cup is an eIF4E-binding protein that functions in smg-mediated translational repression. PMID: 14685270
    8. Cup is a translational repressor of oskar that is required to assemble the oskar mRNA localization machinery. We propose that Cup coordinates localization with translation PMID: 14691132
    9. Cup is required to repress precocious osk translation. Cup binds the 5'-cap binding translation initiation factor eIF4E through a sequence conserved among eIF4E binding proteins. PMID: 14723848
    10. crucial role for the Cup-eukaryotic translation initiation factor 4E (eIF4E) complex in ovary-specific developmental programs. PMID: 15465908
    11. an important downstream effector of a Drosophila forkhead transcription factor phenotype, and regulation of translation by eIF4E is vital during environmental stress PMID: 16055649
    12. This review describes Cup as a multifunctional protein directly and/or indirectly affecting the activity of different mRNAs and proteins by diverse molecular mechanisms in order to achieve a broad range of biological functions. PMID: 17114932
    13. cup, nup154 double mutants exhibit much stronger oogenesis defects than single mutants PMID: 17277377
    14. Sqd, cup, and PABP55B function together to regulate gurken translation. PMID: 18082158
    15. Transcription of comets and cups occurs just before protamines can be detected in spermatid nuclei. PMID: 18482002
    16. Hsp90 interacts in vitro with the translational repressor Cup. PMID: 19101615

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Cytoplasm, Cytoplasmic ribonucleoprotein granule.
  • 組織特異性：
    Predominantly expressed in ovaries and in 0-2 hours old embryos. Weakly expressed in testis. Expressed in young embryos through stage 9, then it decreases throughout the rest of embryogenesis. In ovaries, it is expressed in germ cells throughout pre-vitel
  • 數據庫鏈接：

    KEGG: dme:Dmel_CG11181

    STRING: 7227.FBpp0288761

    UniGene: Dm.333