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  4. Recombinant Drosophila melanogaster Protein pygopus (pygo), partial

Recombinant Drosophila melanogaster Protein pygopus (pygo), partial

  • 中文名稱：
    黑腹果蠅pygo重組蛋白
  • 貨號：
    CSB-YP895583DLU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    黑腹果蠅pygo重組蛋白
  • 貨號：
    CSB-EP895583DLU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    黑腹果蠅pygo重組蛋白
  • 貨號：
    CSB-EP895583DLU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    黑腹果蠅pygo重組蛋白
  • 貨號：
    CSB-BP895583DLU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    黑腹果蠅pygo重組蛋白
  • 貨號：
    CSB-MP895583DLU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    pygo
  • Uniprot No.：
  • 別名：
    pygo; gam; CG11518; Protein pygopus; Protein gammy legs
  • 種屬：
    Drosophila melanogaster (Fruit fly)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in signal transduction through the Wnt pathway.
  • 基因功能參考文獻：
    1. results are consistent with the idea that pygo functions independently of canonical Wnt signaling in the differentiation of the adult interchamber cardiac valves PMID: 24265259
    2. humanized fly Pygo derepresses Notch targets, implying an inherent Notch-related function of classical Pygo orthologs, disabled in fly Pygo, which thus appears dedicated to Wnt signaling. PMID: 24183574
    3. Double knockdown of pygo and Ca2+/calmodulin-dependent protein kinase II caused additional arrhythmia compared with pygo knockdown alone, suggesting that some of the effects of pygo are mediated by Ca2+ signaling. PMID: 24046329
    4. nuclear component of the Wnt signalling pathway; presence of a PHD domain implicates Pygo protein in a chromatin-related function PMID: 11988739
    5. nuclear PHD-finger protein required for Wingless signaling in Drosophila. PMID: 12015286
    6. identifed conserved residues within Pygopus that are required for binding to Legless in vitro and for their activity in development PMID: 14612447
    7. Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. PMID: 16005293
    8. Data show that human and Drosophila Pygo PHD fingers associate with their cognate HD1 domains from BCL9/Legless to bind specifically to the histone H3 tail methylated at lysine 4 (H3K4me). PMID: 18498752
    9. Pygo predisposes Drosophila T cell factor target genes for rapid Wingless-induced transcription, or it protects them against premature shut-down PMID: 19036929
    10. the PHD domain is required to link Drosophila Pygopus to Legless/beta-catenin and not to histone H3 PMID: 19493659

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Ubiquitous throughout embryogenesis and larval development.
  • 數(shù)據(jù)庫鏈接：

    KEGG: dme:Dmel_CG11518

    STRING: 7227.FBpp0085167

    UniGene: Dm.5270