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  4. Recombinant Human A-kinase anchor protein SPHKAP (SPHKAP), partial

Recombinant Human A-kinase anchor protein SPHKAP (SPHKAP), partial

  • 中文名稱：
    人SPHKAP重組蛋白
  • 貨號(hào)：
    CSB-YP639877HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SPHKAP重組蛋白
  • 貨號(hào)：
    CSB-EP639877HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SPHKAP重組蛋白
  • 貨號(hào)：
    CSB-EP639877HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SPHKAP重組蛋白
  • 貨號(hào)：
    CSB-BP639877HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SPHKAP重組蛋白
  • 貨號(hào)：
    CSB-MP639877HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SPHKAP
  • Uniprot No.：
  • 別名：
    A-kinase anchor protein SPHKAP; DKFZp781H143; DKFZp781J171; KIAA1678; MGC132614; MGC132616; SKIP; Sphingosine kinase type 1-interacting protein; SPHK1 (sphingosine kinase type 1) interacting protein; SPHK1 interactor, AKAP domain containing; SPHK1-interacting protein; SPHK1-interactor and AKAP domain-containing protein; sphkap; SPKAP_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1.
  • 基因功能參考文獻(xiàn)：
    1. Results showed that DPP6, SPHKAP and ID4 were down regulated in acute myeloid leukemia (AML) patients. PMID: 22479372
    2. SKIP is an entirely specific type I A-kinase anchoring protein that can sequester two molecules of protein kinase A at mitochondria. PMID: 22084075
    3. sphingosine kinase type 1-interacting protein can be considered as the first mammalian A-kinase-anchoring proteins that preferentially binds to regulatory subunit 1 of cAMP-dependent protein kinase. PMID: 20394097
    4. cloning and characterization; results indicate that SKIP is a novel protein likely to play a regulatory role in the modulation of sphingosine kinase type 1 (SPHK1) activity PMID: 12080051
    5. experiments demonstrate that sphingosine kinase 1/sphingosine-1-phosphate are important components of the transforming growth factor-beta signaling pathway involved in up-regulation of the tissue inhibitor of metalloproteinase-1 (TIMP-1) PMID: 15485866
    6. Uterine expression of SphK1 mediates processes involved in growth and differentiation of uterine tissues during pregnancy. PMID: 17164439
    7. Hyperglycemia stimulates SK1 activity via protein kinase C and oxidative stress-dependent pathways, leading to decreased apoptosis in vvascular smooth muscle. PMID: 17325258
    8. HIF-1 and HIF-2 have roles in SK1 upregulation during hypoxia in glioma cells PMID: 18055454

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  • 亞細(xì)胞定位：
    Cytoplasm. Note=Colocalizes with SPHK1 in the cytoplasm.
  • 蛋白家族：
    AKAP110 family
  • 組織特異性：
    Highly expressed in heart. Both isoforms abundantly expressed in ventricle. Also expressed in spleen, ovary and brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 30619

    OMIM: 611646

    KEGG: hsa:80309

    STRING: 9606.ENSP00000375909

    UniGene: Hs.436306