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  4. Recombinant Human Dexamethasone-induced Ras-related protein 1 (RASD1)

Recombinant Human Dexamethasone-induced Ras-related protein 1 (RASD1)

  • 中文名稱：
    人RASD1重組蛋白
  • 貨號：
    CSB-YP896868HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人RASD1重組蛋白
  • 貨號：
    CSB-EP896868HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人RASD1重組蛋白
  • 貨號：
    CSB-EP896868HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人RASD1重組蛋白
  • 貨號：
    CSB-BP896868HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人RASD1重組蛋白
  • 貨號：
    CSB-MP896868HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    RASD1
  • Uniprot No.：
  • 別名：
    Activator of G protein signaling 1; Activator of G protein signaling; Activator of G-protein signaling 1; AGS 1; AGS1; Dexamethasone induced ras related protein 1; Dexamethasone-induced ras protein 1; Dexamethasone-induced Ras-related protein 1; Dexras 1; MGC:26290; RAS dexamethasone induced 1; Ras protein; Dexamethasone-induced; 1; Ras related protein; RASD 1; Rasd1; RASD1_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達(dá)區(qū)域：
    1-278
  • 氨基酸序列
    MKLAAMIKKM CPSDSELSIP AKNCYRMVIL GSSKVGKTAI VSRFLTGRFE DAYTPTIEDF HRKFYSIRGE VYQLDILDTS GNHPFPAMRR LSILTGDVFI LVFSLDNRDS FEEVQRLRQQ ILDTKSCLKN KTKENVDVPL VICGNKGDRD FYREVDQREI EQLVGDDPQR CAYFEISAKK NSSLDQMFRA LFAMAKLPSE MSPDLHRKVS VQYCDVLHKK ALRNKKLLRA GSGGGGGDPG DAFGIVAPFA RRPSVHSDLM YIREKASAGS QAKDKERC
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65.
  • 基因功能參考文獻(xiàn)：
    1. These findings suggest that the upregulation of RASD1 in glioma tissues may play an inhibitory role in tumor expansion, possibly through inactivating the AKT/mTOR signaling pathway. PMID: 28600528
    2. Studies indicate potential roles for Rasd1 small G protein and leptin in TRPC4 cation channel activation. PMID: 26083271
    3. Data indicate that protein kinase A (PKA) phosphorylates only serine-253 amino acid on activator of G-protein signaling 1 protein Dexras1 (RASD1). PMID: 26358293
    4. Loss of RASD1 is associated with prostate cancer. PMID: 24761910
    5. Study showed that Rasd1 and NonO interact at the CRE-site of specific target genes. PMID: 21915321
    6. Rasd1 modulates endogenous renin gene expression by interacting with Ear2. PMID: 21247419
    7. A glucocorticoid response element (GRE) was identified in the 3'-flanking region (2.3 kb downstream of poly(A) signal) of the human Dexras1 gene. A point mutation within the 15-bp GRE abolished this glucocorticoid responsiveness PMID: 12818426
    8. plays an active role in preventing aberrant cell growth PMID: 15184869
    9. yeast two hybrid analysis and co-immunoprecipitation studies in mammalian cells demonstrate a direct interaction between AGS1 and the G(beta1) subunit of heterotrimeric G proteins PMID: 16225846
    10. does not alter the membrane translocation of protein kinase C delta. PMID: 16489124
    11. Dexras1 plays a critical role in shaping the photic phase response curve (PRC) and the signaling events through which it regulates clock entrainment in transgenic mice. PMID: 17167088
    12. dex-ras1 mRNA is not induced by glucocorticoid stimulation in HEK293 cells PMID: 17985234
    13. Dexras1 functions as a suppressor of FE65-APP-mediated transcription, and FE65 tyrosine 547 phosphorylation enhances FE65-APP-mediated transcription, at least in part, by modulating the interaction between FE65 and Dexras1 PMID: 18922798
    14. Epigenetic inactivation of genes, including RASD1, plays a key role in the development of dexamethasone resistance in multiple myeloma. PMID: 19549772

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  • 亞細(xì)胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, perinuclear region. Nucleus.
  • 蛋白家族：
    Small GTPase superfamily, RasD family
  • 組織特異性：
    Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15828

    OMIM: 605550

    KEGG: hsa:51655

    STRING: 9606.ENSP00000225688

    UniGene: Hs.25829