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  4. Recombinant Human Echinoderm microtubule-associated protein-like 4 (EML4), partial

Recombinant Human Echinoderm microtubule-associated protein-like 4 (EML4), partial

  • 中文名稱：
    人EML4重組蛋白
  • 貨號(hào)：
    CSB-YP862066HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人EML4重組蛋白
  • 貨號(hào)：
    CSB-EP862066HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人EML4重組蛋白
  • 貨號(hào)：
    CSB-EP862066HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人EML4重組蛋白
  • 貨號(hào)：
    CSB-BP862066HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人EML4重組蛋白
  • 貨號(hào)：
    CSB-MP862066HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    EML4
  • Uniprot No.：
  • 別名：
    EML4; C2orf2; Echinoderm microtubule associated protein like 4; Echinoderm microtubule-associated protein-like 4; ELP 120; ELP120; EMAL4_HUMAN; EMAP 4; EMAP-4; EMAP4; EML 4; eml4; Restrictedly overexpressed proliferation associated protein; Restrictedly overexpressed proliferation-associated protein; Ropp 120; ROPP120
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Essential for the formation and stability of microtubules (MTs). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs. Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression.
  • 基因功能參考文獻(xiàn)：
    1. EML4-ALK fusion variant V3 is a high-risk feature for anaplastic lymphoma kinase-driven non-small cell lung cancer PMID: 29363116
    2. The EML4-ALK fusion gene may be a strong oncogene in younger patients with lung adenocarcinoma. PMID: 29517858
    3. lung adenocarcinoma in Asian patients aged 50 years, especially EML4-ALK and ROS1 fusion. Mutation analysis may be helpful in determining targeted therapy for the majority of these patients PMID: 30107055
    4. Mutation testing at diagnosis is feasible in the vast majority of patients with Stage IV adenocarcinoma of the lung. Patients with EGFR or EML4ALK mutation and those who received pemetrexed maintenance had better clinical outcomes. PMID: 29199690
    5. Our analysis indicated that ALK-EML4 positive non-small-cell lung cancers comprised a unique subgroup of adenocarcinomas with distinct clinicopathological characteristics. Incidence of ALK positivity was found to be higher in females and never smokers. PMID: 29199691
    6. Coupling an EML4-ALK-centric interactome with RNA interference identifies sensitizers to ALK inhibitors PMID: 27811184
    7. identified EML4-ALK gene rearrangement in expanded circulating tumor cells from a patient with ALK-positive lung adenocarcinoma PMID: 27507192
    8. Knockdown of SMYD2 as well as treatment with a SMYD2 inhibitor in two NSCLC cell lines with an EML4-ALK gene significantly attenuated the phosphorylation levels of the EML4-ALK protein. PMID: 28370702
    9. The EML4-ALK-mediated upregulation of HIF1alpha, HK2 and glycolytic metabolism was also highly active in vivo as demonstrated by fluorodeoxyglucose-positron emission tomography imaging of xenografts grown from EML4-ALK-positive NSCLC cells. PMID: 27132509
    10. We assessed the prevalence of EML4-ALK rearrangement gene measured by immunohistochemistry in an unselected population-based consecutive cohort of patients with adenocarcinoma of the lung (ACL), and the correlation with smoking history, thyroid transcription factor 1 (TTF1), gender and age PMID: 27943404
    11. Our findings show that group EML4-ALK variants 3a/b in non-small cell lung cancer may be a major source of ALK inhibitor resistance in the clinic. PMID: 28039177
    12. EML4-ALK rearrangement detection in malignant pleural effusions is a complementary method for EML4-ALK detection. VETANA and qRT-PCR are more appropriate for MPE detection. EML4-ALK rearrangement in pleural effusions has a predictive value for treatment. PMID: 27060609
    13. EML4-ALK-positive lung cancer is often highly progressive. PMID: 26964537
    14. case report in which the EML4-ALK fusion gene was identified as a second primary lung cancer after surgically resecting EGFR mutation-positive adenocarcinoma PMID: 26704814
    15. 79 (69%) were negative for echinoderm microtubule-associated protein like 4 (EML4)-ALK translocation, nine (8%) were positive and 27 (23%) were unevaluable. PMID: 25757141
    16. Data suggest that platelets are a valuable source for the non-invasive detection of echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangements and for predicting and monitoring outcome to crizotinib. PMID: 26544515
    17. Data show that inhibition of echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK)-mediated stem-like properties enhances the anti-tumor effect. PMID: 26517679
    18. This review describes the biology of EML4 and ALK, explains the main features of EML4-ALK fusion proteins and outline the therapies that target EML4-ALK in cancer. [review] PMID: 26755435
    19. We further showed that both EML4-ALK and mutant forms of EGFR modulate PD-L1 expression via common downstream pathways mediated by MEK-ERK and by PI3K-AKT. PMID: 26019170
    20. EGFR gene mutations and the EML4-ALK fusion gene were detected in 92 lung adenocarcinoma patients in China. PMID: 24935562
    21. In the absence of EML4, NUDC was no longer able to localize to the mitotic spindle, whereas NUDC was dispensable for EML4 localization. PMID: 25789526
    22. It was revealed that the EML4-ALK fusion gene was observed predominantly in adenocarcinoma, non-smoking and non-small-cell lung cancers (NSCLC) patients, especially those diagnosed in the advanced clinical stage of NSCLC. PMID: 25706305
    23. Results suggested that chromothripsis may be a mechanism of oncogenic rearrangement of EML4-ALK. PMID: 25144242
    24. The FISH-based method of detecting EML4-ALK rearrangement in lung cancer may miss a significant number of patients who could benefit from targeted ALK therapy. IHC should be strongly considered, and NGS is recommended in borderline cases. PMID: 25721120
    25. H1299 NSCLC cells stably expressing EML4-ALK acquire epithelial-mesenchymal transition (EMT) phenotype, associated with enhanced invasive migration and increased expression of EMT-inducing transcription factors. PMID: 25735977
    26. Results suggest that heat shock protein 90 (Hsp90) inhibitors may overcome ligand-triggered resistance in microtubule associated protein-like 4 (EML4)--anaplastic lymphoma kinase (ALK) lung cancer cells. PMID: 24952482
    27. EML4 genetic translocation is a therapeutic target in the treatment of aggressive papillary cancer of the thyroid. PMID: 24633422
    28. Letter/Case Report: lung adenocarcinoma where EML4-ALK gene rearrangement was missed by FISH techniques but detected using reverse transcriptase PCR. PMID: 25028527
    29. EML4-ALK gene rearrangements do not appear to be involved in the development of primary adenocarcinoma of the urinary bladder. PMID: 23887300
    30. EML4-ALK fusion genepositivitymightbe higher inyoungerNSCLCpatientswithwild-type EGFR. PMID: 24388371
    31. EML4-ALK fusion is uncommon, reported in about 5% of NSCLC patients. PMID: 24346098
    32. NSCLC patients with the EML4-ALK fusion gene might be relatively insensitivite to cytotoxic chemotherapy. PMID: 24982409
    33. Hsp90-sensitive EML4-ALK variants are exceptions to the rule that oncogenic fusion proteins involve breakpoints in disordered regions of both partners PMID: 24706829
    34. The first report concerning the presence of the EML4-ALK fusion gene in a sarcomatoid carcinoma of the lung. PMID: 23664446
    35. evaluated mutations in four driver genes, epidermal growth factor receptor (EGFR), Kirsten ras oncogene (KRAS), c-MET, and echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), in Chinese lung adenocarcinoma patients PMID: 23919423
    36. This case suggests that echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion is an oncogenic event in not only carcinomas but also sarcomas originating from stromal cells. PMID: 24277751
    37. EML4-ALK rearrangement is associated with congenital pulmonary airway malformation. PMID: 23357247
    38. EML4-ALK rearrangements are associated with lung carcinomas. PMID: 23408463
    39. EML4-ALK rearrangement is associated with response to therapy in lung adenocarcinoma. PMID: 23486270
    40. variations in EML4-ALK fusion is associated with small-cell lung cancer with adenocarcinoma. PMID: 23154565
    41. EML4-ALK fusion variant is associated with non-small-cell lung cancer. PMID: 23169500
    42. Lung neoplasm patients who harbor EML4-ALK fusion genes generally have wild type EGFR and KRAS genes. PMID: 22736493
    43. EML4-ALK variant is associated with lung cancer. PMID: 22706607
    44. EML4-ALK-variations are associated with non-small cell lung cancer. PMID: 22722791
    45. EML4-ALK and low thymidylate synthase expression is associated with treatment outcome with pemetrexed in Non-Small Cell Lung Cancer. PMID: 22056890
    46. EML4-anaplastic lymphoma kinase (ALK) fusion gene is associated with longer overall survival of lung adenocarcinoma patients with wild-type epidermal growth factor receptor mutations. PMID: 22124476
    47. frequent rearrangement in lung signet-ring cell carcinoma PMID: 21036415
    48. New molecular targets are on investigation, such as EML4-ALK translocation. PMID: 21420271
    49. EML4-ALK fusion variants have a role in non-small cell lung cancer PMID: 21356191
    50. EML4-ALK fusion appears to be tightly associated with ALK mRNA expression levels. RACE-coupled PCR sequencing is a highly sensitive method that could be used clinically for the identification of EML4-ALK-positive patients PMID: 20624322

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  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center. Midbody.
  • 蛋白家族：
    WD repeat EMAP family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 1316

    OMIM: 607442

    KEGG: hsa:27436

    STRING: 9606.ENSP00000320663

    UniGene: Hs.713173