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  4. Recombinant Human Ewing's tumor-associated antigen 1 (ETAA1), partial

Recombinant Human Ewing's tumor-associated antigen 1 (ETAA1), partial

  • 中文名稱：
    人ETAA1重組蛋白
  • 貨號：
    CSB-YP868354HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ETAA1重組蛋白
  • 貨號：
    CSB-EP868354HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ETAA1重組蛋白
  • 貨號：
    CSB-EP868354HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ETAA1重組蛋白
  • 貨號：
    CSB-BP868354HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ETAA1重組蛋白
  • 貨號：
    CSB-MP868354HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ETAA1
  • Uniprot No.：
  • 別名：
    Etaa1; ETAA1_HUMAN; ETAA16; Ewing''s tumor-associated antigen 1; Ewing''s tumor-associated antigen 16
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Replication stress response protein that accumulates at DNA damage sites and promotes replication fork progression and integrity. Recruited to stalled replication forks via interaction with the RPA complex and directly stimulates ATR kinase activity independently of TOPBP1. Probably only regulates a subset of ATR targets.
  • 基因功能參考文獻(xiàn)：
    1. These our data suggest that ETAA1 is a new ATR activator involved in replication checkpoint control. PMID: 27818175
    2. results reveal that ETAA1 is a novel RPA-interacting protein that promotes restart of stalled replication forks. PMID: 27601467
    3. that parallel TopBP1- and ETAA1-mediated pathways underlie ATR activation and that their combined action is essential for coping with replication stress PMID: 27723717
    4. ETAA1 acts as a direct ATR serine-threonine kinase protein activator PMID: 27723720
    5. results suggest that ETAA16 may function as a tumour-specific cell surface antigen in Ewing's family of tumors PMID: 16003559

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Expressed at high levels in the brain, liver kidney and Ewing tumor cell lines.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24648

    OMIM: 613196

    KEGG: hsa:54465

    STRING: 9606.ENSP00000272342

    UniGene: Hs.353022