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  4. Recombinant Human Oligodendrocyte transcription factor 1 (OLIG1), partial

Recombinant Human Oligodendrocyte transcription factor 1 (OLIG1), partial

  • 中文名稱：
    人OLIG1重組蛋白
  • 貨號(hào)：
    CSB-YP016328HU
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    OLIG1
  • Uniprot No.：
  • 別名：
    Basic domain helix loop helix protein class B 6; Basic domain helix loop helix protein class B6; BHLH B6; BHLHB 6; bHLHb6; bHLHe21; Class B basic helix-loop-helix protein 6; Class E basic helix-loop-helix protein 21; Olig 1; Olig1; OLIG1_HUMAN; Oligo 1; Oligo1; Oligodendrocyte lineage transcription factor 1; Oligodendrocyte specific bHLH transcription factor 1; Oligodendrocyte transcription factor 1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Partial
  • 來(lái)源：
    Yeast
  • 分子量：
    11.1 kDa
  • 表達(dá)區(qū)域：
    17-105aa
  • 氨基酸序列
    MLRPQRPGDLQLGASLYELVGYRQPPSSSSSSTSSTSSTSSSSTTAPLLPKAAREKPEAPAEPPGPGPGSGAHPGGSARPDAKEEQQQQ
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer,50% glycerol
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
  • 基因功能參考文獻(xiàn)：
    1. Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin. PMID: 28253550
    2. This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
    3. Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility PMID: 23720758
    4. This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states. PMID: 23165259
    5. Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance. PMID: 21446039
    6. analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus PMID: 21206754
    7. Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification. PMID: 16267213
    8. identified novel coding variants in the Olig1 gene, including a trinucleotide repeat, but found no evidence to support the hypothesis that genetic variation in Olig1 influences susceptibility to multiple sclerosis PMID: 16820418
    9. Mutations in OLIG1 and OLIG2 are not likely to be associated with this subgroup of hypomyelinating disorders. PMID: 17171653
    10. OLIG1 protein expression significantly correlates with overall survival in non-small cell lung cancer patients PMID: 17388669
    11. No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-1 expression. PMID: 17690840

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16983

    OMIM: 606385

    KEGG: hsa:116448

    STRING: 9606.ENSP00000371785

    UniGene: Hs.56663