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OLIG1 Antibody, Biotin conjugated

  • 中文名稱：
    OLIG1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA016328LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) OLIG1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    OLIG1
  • 別名：
    Basic domain helix loop helix protein class B 6 antibody; Basic domain helix loop helix protein class B6 antibody; BHLH B6 antibody; BHLHB 6 antibody; bHLHb6 antibody; bHLHe21 antibody; Class B basic helix-loop-helix protein 6 antibody; Class E basic helix-loop-helix protein 21 antibody; Olig 1 antibody; Olig1 antibody; OLIG1_HUMAN antibody; Oligo 1 antibody; Oligo1 antibody; Oligodendrocyte lineage transcription factor 1 antibody; Oligodendrocyte specific bHLH transcription factor 1 antibody; Oligodendrocyte transcription factor 1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Oligodendrocyte transcription factor 1 protein (17-105AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube.
  • 基因功能參考文獻(xiàn)：
    1. Olig1 has a critical function in regulation of postnatal neural progenitor cell production in response to Noggin. PMID: 28253550
    2. This study demonstrated that increased expression of mRNA of OLIG1 in ventral prefrontal white matter in major depressive disorder. PMID: 25930075
    3. Olig1 is a Smad cofactor involved in TGF-beta-induced cell motility PMID: 23720758
    4. This study review OLIG1 have developmental functions in patterning, neuron subtype specification and the formation of oligodendrocytes and play the role in the postnatal brain during repair processes and in neurological disease states. PMID: 23165259
    5. Olig1 was not expressed in freshly isolated oligodendrocytes, but is expressed from the beginning of process extension until membrane maintenance. PMID: 21446039
    6. analysis of conserved and non-conserved functional elements at the Olig1 and Olig2 locus PMID: 21206754
    7. Olig1 and Olig2 transcription factors in the human central nervous system are important not only for differentiation of the oligodendrocyte lineage, but they may also have a role in neural cell specification. PMID: 16267213
    8. identified novel coding variants in the Olig1 gene, including a trinucleotide repeat, but found no evidence to support the hypothesis that genetic variation in Olig1 influences susceptibility to multiple sclerosis PMID: 16820418
    9. Mutations in OLIG1 and OLIG2 are not likely to be associated with this subgroup of hypomyelinating disorders. PMID: 17171653
    10. OLIG1 protein expression significantly correlates with overall survival in non-small cell lung cancer patients PMID: 17388669
    11. No significan correlation was found between proliferation index in pilocytic astrocytomas and Olig-1 expression. PMID: 17690840

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  • 亞細(xì)胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas is highly variable.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16983

    OMIM: 606385

    KEGG: hsa:116448

    STRING: 9606.ENSP00000371785

    UniGene: Hs.56663