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  4. Recombinant Human Rho guanine nucleotide exchange factor 26 (ARHGEF26), partial

Recombinant Human Rho guanine nucleotide exchange factor 26 (ARHGEF26), partial

  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-YP850280HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-EP850280HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-EP850280HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-BP850280HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Rho guanine nucleotide exchange factor 26(ARHGEF26) ,partial
  • 貨號：
    CSB-MP850280HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ARHGEF26
  • Uniprot No.：
  • 別名：
    ARHGEF26; SGEF; HMFN1864; Rho guanine nucleotide exchange factor 26; SH3 domain-containing guanine exchange factor
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
  • 基因功能參考文獻(xiàn)：
    1. SGEF plays a role in activating RhoG during invadopodia disassembly PMID: 28202690
    2. High SGEF expression is associated with lung adenocarcinoma. PMID: 29454349
    3. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes. PMID: 28714974
    4. yrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF PMID: 27437949
    5. Data support evidence for SGEF role in both the promotion of cell invasion and cell survival signaling within glioblastoma tumors and promoting chemotherapeutic resistance. PMID: 26764186
    6. A novel function of SGEF that excludes GEF. PMID: 24399467
    7. We report for the first time an SGEF function for RhoG that excludes GEF and the ability of SGEF to enhance EGFR stability and signaling by delaying its lysosomal sorting and degradation PMID: 23661635
    8. Data indicate that the Src homology 3 domain-containing GEF (SGEF) promotes fibroblast growth factor-inducible 14 (Fn14) proinvasive signaling in glioblastoma via TNF receptor-associated factor 2 (TRAF2). PMID: 23775076
    9. SGEF is a novel promoter of human prostate cancer progression and development. PMID: 22824926
    10. The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. PMID: 22383878
    11. SGEF gene on chromosome 3q25.2. CSGEF expression controlled by androgen-responsive promoter of SGEF gene. SGEF may be regulator of Rho guanosine triphosphatases. CSGEF may function as regulator of Rho guanosine triphosphatase in prostate PMID: 12697679

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  • 亞細(xì)胞定位：
    Cell projection, ruffle.
  • 組織特異性：
    Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24490

    OMIM: 617552

    KEGG: hsa:26084

    STRING: 9606.ENSP00000348828

    UniGene: Hs.240845