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  4. Recombinant Human Semenogelin-2 (SEMG2)

Recombinant Human Semenogelin-2 (SEMG2)

  • 中文名稱：
    人SEMG2重組蛋白
  • 貨號(hào)：
    CSB-YP021002HU
  • 規(guī)格：
    ￥2208
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    SEMG2; Semenogelin-2; Semenogelin II; SGII
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length of Mature Protein
  • 來源：
    Yeast
  • 分子量：
    64.9kDa
  • 表達(dá)區(qū)域：
    24-582aa
  • 氨基酸序列
    QKGGSKGQLPSGSSQFPHGQKGQHYFGQKDQQHTKSKGSFSIQHTYHVDINDHDWTRKSQQYDLNALHKATKSKQHLGGSQQLLNYKQEGRDHDKSKGHFHMIVIHHKGGQAHHGTQNPSQDQGNSPSGKGLSSQCSNTEKRLWVHGLSKEQASASGAQKGRTQGGSQSSYVLQTEELVVNKQQRETKNSHQNKGHYQNVVDVREEHSSKLQTSLHPAHQDRLQHGPKDIFTTQDELLVYNKNQHQTKNLSQDQEHGRKAHKISYPSSRTEERQLHHGEKSVQKDVSKGSISIQTEEKIHGKSQNQVTIHSQDQEHGHKENKISYQSSSTEERHLNCGEKGIQKGVSKGSISIQTEEQIHGKSQNQVRIPSQAQEYGHKENKISYQSSSTEERRLNSGEKDVQKGVSKGSISIQTEEKIHGKSQNQVTIPSQDQEHGHKENKMSYQSSSTEERRLNYGGKSTQKDVSQSSISFQIEKLVEGKSQIQTPNPNQDQWSGQNAKGKSGQSADSKQDLLSHEQKGRYKQESSESHNIVITEHEVAQDDHLTQQYNEDRNPIST
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    A truncated version of Semenogelin-2/SEMG2 lacking the 1-23 amino-acid signal peptide of the C-terminus and carrying a 6xHis-tag at the N-terminus was produced in the yeast. The resulting protein is a full-length of mature SEMG2 protein. It contains aa of 24-582 of the human SEMG2 protein. It was purified by SDS-PAGE and reached up to 90% in purity. On the reducing SDS-PAEG gel, this SEMG2 protein migrated on the molecular weight band of about 65 kDa. The result is slightly higher than that of the calculated one due to glycosylation. This recombinant SEMG2 protein may be used to produce specific antibodies or on the SEMG2-associated signal transduction.

    SEMG2 also referred to as SgII, is secreted by the seminal vesicles. Together with SgII and fibronectin, SEMG2 is involved in the formation of the coagulum formed by newly ejaculated human semen. Upon semenogelins' proteolysis by prostate-specific antigen (PSA), the sperm coagulum was liquefied within 5-20 minutes and released the trapped spermatozoa and accessory gland secretions. Besides, SEMG2 interaction with transglutaminase and activation to sperm hyaluronidase shows that it also participates in the degradation of the envelope around the ovum during fertilization.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa.
  • 基因功能參考文獻(xiàn)：
    1. SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea. PMID: 12200457
    2. SGII is a novel target for protein S-nitrosylation in spermatozoa. PMID: 17683036
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Semenogelin family
  • 組織特異性：
    Seminal vesicles, and to a much lesser extent, epididymis.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 10743

    OMIM: 182141

    KEGG: hsa:6407

    STRING: 9606.ENSP00000361855

    UniGene: Hs.537218