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  4. Recombinant Human Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC), partial

Recombinant Human Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC), partial

  • 中文名稱：
    人PPP3CC重組蛋白
  • 貨號：
    CSB-EP018574HU
  • 規(guī)格：
    ￥1344
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    calcineurin A gamma; CALCINEURIN A3; Calcineurin; Calcineurin testis specific catalytic subunit; Calmodulin dependent calcineurin A subunit gamma isoform; Calmodulin-dependent calcineurin A subunit gamma isoform; CALNA3 ; CAM PRP catalytic subunit; CAM-PRP catalytic subunit; CNA3 ; pp2b gamma; PP2BC_HUMAN; PP2Bgamma; PPP3CC; protein phosphatase 3 (formerly 2B) catalytic subunit gamma isoform (calcineurin A gamma) ; protein phosphatase 3 (formerly 2B) catalytic subunit gamma isoform; Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform; testis-specific catalytic subunit
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    62.0kDa
  • 表達區(qū)域：
    2-512aa
  • 氨基酸序列
    SGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKSVTSAHSHAAHRSDQGKKAHS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals. Dephosphorylates and activates transcription factor NFATC1. Dephosphorylates and inactivates transcription factor ELK1. Dephosphorylates DARPP32.
  • 基因功能參考文獻：
    1. PPP3CC rs7431 may alter miRNA binding ability of miR-212 and miR-132, and thus decrease bladder cancer risk. PMID: 29275364
    2. These findings indicated that the down-regulation of PPP3CC by ZEB1 resulted in activation of NF-kappaB is a critical oncogenic event in gliomas. PMID: 29294030
    3. The rs2443504 AA genotype was associated with the Glasgow coma score at 3, 6, and 12 months following severe brain injury. PMID: 27225880
    4. Knockdown of CNAgamma leads to a disruption of synaptic vesicle cycling in hippocampal neurons. PMID: 26627835
    5. The PPP3CC involved in the regulation of immune system and synaptic plasticity, seems promising for further investigation. PMID: 24709691
    6. protein level of PPP3CC negatively correlates with the cellular level of IP3, suggesting a regulatory role of PPP3CC in the IP3-Ca2+ signaling pathway PMID: 23747857
    7. study suggests that NMDA receptor-mediated signalling genes, DAO, PPP3CC, DTNBP1 might be involved in schizophrenia pathogenic mechanisms related to gender PMID: 23497497
    8. This study demoistrated that PPP3CC are not genetic risk factors for schizophrenia in japanese. PMID: 20537399
    9. results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis PMID: 12851458
    10. Decreased hippocampal expression of the susceptibility gene PPP3CC in schizophrenia. PMID: 15820226
    11. PPP3CC may not play a major role in Japanese schizophrenia PMID: 15843870
    12. The results suggest that PPP3CC gene may be a true susceptibility gene for schizophrenia. PMID: 17339875
    13. The Polymorphism, Single Nucleotide of ppp3cc is assosciated with schizophrenia. PMID: 17895921
    14. No significant differences in calcineurin A gamma expression was observed between patients with schizophrenia and normal controls PMID: 18343007
    15. Data suggest that PPP3CC does not elevate the risk of methamphetamine-use disorder in the Japanese population. PMID: 18991849

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  • 蛋白家族：
    PPP phosphatase family, PP-2B subfamily
  • 組織特異性：
    Testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9316

    OMIM: 114107

    KEGG: hsa:5533

    STRING: 9606.ENSP00000240139

    UniGene: Hs.731683