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  4. Recombinant Human StAR-related lipid transfer protein 4 (STARD4)

Recombinant Human StAR-related lipid transfer protein 4 (STARD4)

  • 中文名稱：
    人STARD4重組蛋白
  • 貨號：
    CSB-YP853403HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人STARD4重組蛋白
  • 貨號：
    CSB-EP853403HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人STARD4重組蛋白
  • 貨號：
    CSB-EP853403HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人STARD4重組蛋白
  • 貨號：
    CSB-BP853403HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人STARD4重組蛋白
  • 貨號：
    CSB-MP853403HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    STARD4
  • Uniprot No.：
  • 別名：
    4632419C16Rik; 9030213J02Rik; AA517649; AW324468; StAR related lipid transfer (START) domain containing 4; StAR-related lipid transfer protein 4; STAR4_HUMAN; StARD4; START domain containing 4 sterol regulated; START domain-containing protein 4
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-205
  • 氨基酸序列
    MEGLSDVASF ATKLKNTLIQ YHSIEEDKWR VAKKTKDVTV WRKPSEEFNG YLYKAQGVID DLVYSIIDHI RPGPCRLDWD SLMTSLDILE NFEENCCVMR YTTAGQLWNI ISPREFVDFS YTVGYKEGLL SCGISLDWDE KRPEFVRGYN HPCGWFCVPL KDNPNQSLLT GYIQTDLRGM IPQSAVDTAM ASTLTNFYGD LRKAL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the intracellular transport of cholesterol. Binds cholesterol or other sterols.
  • 基因功能參考文獻：
    1. This study shows that nonvesicular sterol transport mechanisms and STARD4 in particular account for a large fraction of sterol transport between the plasma membrane and the ERC. PMID: 28209730
    2. The data indicate a role for STARD4 in nonvesicular transport of cholesterol from the plasma membrane and the endocytic recycling compartment to the endoplasmic reticulum and perhaps other intracellular compartments as well. PMID: 23033213
    3. cholesterol transport mediated by STARD4 is an important component of the cholesterol homeostasis regulatory machinery PMID: 21900492
    4. Study provide strong evidence for StarD4 as a highly regulated, non-vesicular, directional, intracellular transporter of cholesterol which plays a key role in the maintenance of intracellular cholesterol homeostasis. PMID: 21767660
    5. StarD4-accelerated 7 alpha-OOH transfer to mitochondria resulted in greater susceptibility to free radical lipid peroxidation and loss of membrane potential than in a non-StarD4 control. PMID: 20059974
    6. Induction of STARD4 depended on both transcription factor ATF6 and an ERSE-like element in its promoter. PMID: 16579971
    7. StarD4 plays an important role as a directional cholesterol transporter in the maintenance of cellular cholesterol homeostasis PMID: 18403318

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  • 數(shù)據(jù)庫鏈接：

    HGNC: 18058

    OMIM: 607049

    KEGG: hsa:134429

    STRING: 9606.ENSP00000296632

    UniGene: Hs.732430