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  4. Recombinant Human Transcription cofactor vestigial-like protein 3 (VGLL3)

Recombinant Human Transcription cofactor vestigial-like protein 3 (VGLL3)

  • 中文名稱：
    人VGLL3重組蛋白
  • 貨號(hào)：
    CSB-YP025850HU
  • 規(guī)格：
    ￥1500
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    VGLL3; Transcription cofactor vestigial-like protein 3; Vgl-3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full Length of Isoform 2
  • 來源：
    Yeast
  • 分子量：
    37.2kDa
  • 表達(dá)區(qū)域：
    1-320aa
  • 氨基酸序列
    MSCAEVMYHPQPYGASQYLPNPMAATTCPTAYYQPAPQPGQQKKLAVFSKMQDSLEVTLPSKQEEEDEEEEEEEKDQPAEMEYLNSRCVLFTYFQGDIGSVVDEHFSRALGQAITLHPESAISKSKMGLTPLWRDSSALSSQRNSFPTSFWTSSYQPPPAPCLGGVHPDFQVTGPPGTFSAADPSPWPGHNLHQTGPAPPPAVSESWPYPLTSQVSPSYSHMHDVYMRHHHPHAHMHHRHRHHHHHHHPPAGSALDPSYGPLLMPSVHAARIPAPQCDITKTEPTTVTSATSAWAGAFHGTVDIVPSVGFDTGWSAMARS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    A cDNA encoding residues Met1 to Ser320 of the human Transcription cofactor vestigial-like protein 3 (VGLL3) full-length protein was fused with a 6xHis-tag at the N-terminus and then expressed in the yeast. The forming recombinant protein was validated by SDS-PAGE. Its purity is greater than 90%. On the reducing SDS-PAGE gel, the VGLL3 protein migrated on the molecular mass band of approximately 38 kDa. The slightly higher result is attributed to glycosylation. This recombinant VGLL3 protein can act as the immunogen to produce specific antibodies. Besides, it also may be used in the studies of VGLL3-associated transcription.

    VGLL3 is a co-activator of mammalian toxicity equivalency factors (TEFs). It has reported participating in the proliferation of sarcoma and breast tumor cells. Studies revealed that VGLL3 expression was positively correlated with poor prognostic outcome in patients with gastric tumor. And gastric tumor with high levels of VGLL3 showed the activation of the MAPK, JAK-STAT, and WNT pathways together with enhanced immune infiltrates.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May act as a specific coactivator for the mammalian TEFs.
  • 基因功能參考文獻(xiàn)：
    1. this study identified a VGLL3-regulated network as a previously unknown inflammatory pathway that promotes female-biased autoimmunity PMID: 27992404
    2. VGLL3 is involved in tumor suppressor pathways, a feature that is characterized by the absence of VGLL3 expression in high-grade serous ovarian carcinomas samples. PMID: 23415753
    3. vestigial-like 3 (Vgll3) is an inhibitor of adipogenesis PMID: 23152581
    4. data suggest that the amplification and overexpression of YAP1 and VGLL3 could be involved in oncogenesis and progression of soft tissue sarcomas PMID: 20842732
    5. This protein was named Vestigial-like 3, because it is related to the Drosophila protein Vestigial. Like other members of this family, it contains a consensus TEF-1 and MEF2(TDU)interaction domain. PMID: 12376544

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Vestigial family
  • 組織特異性：
    Enriched in placenta.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24327

    OMIM: 609980

    KEGG: hsa:389136

    STRING: 9606.ENSP00000381436

    UniGene: Hs.606507