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  4. Recombinant Human Uncharacterized protein C6orf106 (C6orf106)

Recombinant Human Uncharacterized protein C6orf106 (C6orf106)

  • 中文名稱：
    Recombinant Human Uncharacterized protein C6orf106(C6orf106)
  • 貨號：
    CSB-YP863990HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Uncharacterized protein C6orf106(C6orf106)
  • 貨號：
    CSB-EP863990HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Uncharacterized protein C6orf106(C6orf106)
  • 貨號：
    CSB-EP863990HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Uncharacterized protein C6orf106(C6orf106)
  • 貨號：
    CSB-BP863990HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Uncharacterized protein C6orf106(C6orf106)
  • 貨號：
    CSB-MP863990HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    C6orf106
  • Uniprot No.：
  • 別名：
    C6orf106; CF106_HUMAN; Chromosome 6 open reading frame 106; dJ391O22.4; FLJ22195; RP3-391O22.4; Uncharacterized protein C6orf106
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-298
  • 氨基酸序列
    MEGMDVDLDP ELMQKFSCLG TTDKDVLISE FQRLLGFQLN PAGCAFFLDM TNWNLQAAIG AYYDFESPNI SVPSMSFVED VTIGEGESIP PDTQFVKTWR IQNSGAEAWP PGVCLKYVGG DQFGHVNMVM VRSLEPQEIA DVSVQMCSPS RAGMYQGQWR MCTATGLYYG DVIWVILSVE VGGLLGVTQQ LSSFETEFNT QPHRKVEGNF NPFASPQKNR QSDENNLKDP GGSEFDSISK NTWAPAPDTW APAPDQTEQD QNRLSQNSVN LSPSSHANNL SVVTYSKGLH GPYPFGQS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP.
  • 基因功能參考文獻：
    1. High C6orf106 expression was significantly correlated with lymph node metastasis in triple-negative breast cancer. PMID: 25953261
    2. C6orf106 promotes invasion in NSCLC cells. Finally, C6orf106 upregulates vimentin, and downregulates E-cadherin and P120ctn. PMID: 25736925
    3. Ethanol, but not acetaldehyde, inhibited PPAR-beta transactivation. PMID: 18003597
    4. DSCR2 was found to interact with PPARbeta and to inhibit it. PMID: 18793612
    5. up-regulated expression by repetitive low-grade oxidative stress through p38MAPK or NF-kappaB pathways PMID: 19059477

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Expressed in lung (at protein level).
  • 數據庫鏈接：

    HGNC: 21215

    OMIM: 612217

    KEGG: hsa:64771

    STRING: 9606.ENSP00000363135

    UniGene: Hs.643498