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  4. Recombinant Mouse Alsin (Als2), partial

Recombinant Mouse Alsin (Als2), partial

  • 中文名稱：
    Recombinant Mouse Alsin(Als2) ,partial
  • 貨號：
    CSB-YP835624MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Alsin(Als2) ,partial
  • 貨號：
    CSB-EP835624MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Alsin(Als2) ,partial
  • 貨號：
    CSB-EP835624MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Alsin(Als2) ,partial
  • 貨號：
    CSB-BP835624MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Alsin(Als2) ,partial
  • 貨號：
    CSB-MP835624MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Als2
  • Uniprot No.：
  • 別名：
    Als2; Alsin; Amyotrophic lateral sclerosis 2 protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May act as a GTPase regulator. Controls survival and growth of spinal motoneurons.
  • 基因功能參考文獻(xiàn)：
    1. two ALS-linked factors, SQSTM1 and ALS2, have distinct but additive protective roles against mutant SOD1-mediated toxicity by modulating neuronal proteostasis possibly through the autophagy-endolysosomal system. PMID: 27439389
    2. By taking advantage of this CSMN reporter line of AlsinKO, authors reveal that apical dendrite degeneration is a common cellular pathology for CSMN that become diseased for different causes. PMID: 26755825
    3. alsin and spartin may interact each other physically. PMID: 22982304
    4. Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity. PMID: 21937428
    5. these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB pathway. PMID: 21907703
    6. Rab5-mediated endocytosis was severely altered in ALS2(-/-) neurons. PMID: 19630956
    7. ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking PMID: 20339559
    8. Als2(-/-) mice showed a significantly lower spontaneous rearing activity than wild-type litters. These genetic background- and/or gender-specific findings suggest the presence of modifiers for life span and motor activities in Als2(-/-) mice. PMID: 20558214
    9. Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor PMID: 15033976
    10. Rac1, PI3 kinase, and Akt3 have roles in an anti-apoptotic pathway triggered by ALS2 that antagonizes SOD1 mutant-induced motoneuronal cell death PMID: 15579468
    11. loss of ALS2 function is not sufficient to cause motor neuron disease in a mouse model. However, lack of ALS2 did predispose neurons to oxidative stress, implying that ALS2 might serve as a risk factor for motor neuron disease. PMID: 16107644
    12. The homozygous deletion in exon 4 of the ALS2 gene (553delA). PMID: 16240357
    13. Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking. PMID: 16321985
    14. Altered trophic receptor trafficking in neurons of Als2(-/-) mice may underlie the histopathological and behavioral changes observed and the pathogenesis of ALS2 PMID: 16769894
    15. deficiency in ALS2 causes an upper motor neuron disease that closely resembles a severe form of hereditary spastic paralysis, and that is quite distinct from amyotrophic lateral sclerosis. PMID: 16802286
    16. alsin controls the growth and survival of motoneurons in a Rac1-dependant manner PMID: 16802292
    17. Our data suggest that deficiency in the ALS2 gene does not affect the pathogenesis of SOD1(G93A) mice. PMID: 16973244
    18. Novel function of ALS2 gene in lymphopoiesis and hematopoiesis, suggesting that immune system is involved in pathogenesis of one form of juvenile onset autosomal recessive amyotrophic lateral sclerosis(ALS2). PMID: 17156857
    19. ALS2 is a novel Rac1 effector and is involved in Rac1-activated macropinocytosis. PMID: 17409386
    20. alsin-deficient mice have motor impairment and degenerative pathology in the distal corticospinal tracts without apparent motor neuron pathology PMID: 17855450
    21. Mouse models fail to recapitulate hallmarks of motor neuron disease, but the subtle deficits are observed in behavior and pathology. [RREVIEW] PMID: 17955197
    22. ALS2 may act as a modulator in neuronal differentiation and/or development through regulation of membrane dynamics. PMID: 18358238
    23. The Als2(-/-) mice lacking exon 2 and part of exon 3 developed mild signs of neurodegeneration compatible with axonal transport deficiency. PMID: 18558633
    24. Als2-depleted spinal motor neurons can be rescued by co-cultured astrocytes. PMID: 19304783

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