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  4. Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Arap3), partial

Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Arap3), partial

  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(Arap3) ,partial
  • 貨號：
    CSB-YP823193MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(Arap3) ,partial
  • 貨號：
    CSB-EP823193MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(Arap3) ,partial
  • 貨號：
    CSB-EP823193MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(Arap3) ,partial
  • 貨號：
    CSB-BP823193MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3(Arap3) ,partial
  • 貨號：
    CSB-MP823193MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Arap3; Centd3; Drag1; Kiaa4097; Arf-GAP with Rho-GAP domain; ANK repeat and PH domain-containing protein 3; Centaurin-delta-3; Cnt-d3; Dual specificity Rho- and Arf-GTPase-activating protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts preferentially on ARF5 and on RHOA.
  • 基因功能參考文獻：
    1. Deletion of Arap3 in osteoblasts and mesenchymal stromal cells using Prx1-Cre resulted in no discernable phenotypes in hematopoietic development or hematopoietic stem cells homeostasis in adult mice. PMID: 25542002
    2. Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. PMID: 24163130
    3. We report here the first characterization of the role of ARAP3 in murine neutrophils PMID: 21490342
    4. PI3K signaling through the dual GTPase-activating protein ARAP3 is essential for developmental angiogenesis. PMID: 20978237
    5. ARAP3 has a role in integrin-mediated tyrosine kinase signalling pathways controlling Rho GTPases and cell spreading PMID: 15546919
    6. the Nck adapters are needed for signaling to Rho GTPases and actin dynamics downstream of the PDGFbeta receptor PMID: 18765673

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  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Note=Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia.
  • 數(shù)據(jù)庫鏈接：