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  4. Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial

Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial

In Stock
  • 中文名稱：
    Recombinant Mouse B-cell differentiation antigen CD72 (Cd72), partial
  • 貨號：
    CSB-MP004955MO1
  • 規(guī)格：
    ￥2376
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性：
    Not Test
  • 基因名：
  • Uniprot No.：
  • 別名：
    Lyb-2;Lymphocyte antigen 32;Ly-32;CD antigen CD72
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 來源：
    Mammalian cell
  • 分子量：
    54.3 kDa
  • 表達(dá)區(qū)域：
    117-354aa
  • 氨基酸序列
    RYLQVSRQFQEGTRIWEATNSSLQQQLREKISQLGQKEVELQKARKELISSQDTLQEKQRTHEDAEQQLQACQAERAKTKENLKTEEERRRDLDQRLTSTRETLRRFFSDSSDTCCPCGWIPYQERCFYISHTLGSLEESQKYCTSLSSKLAAFDEPSKYYYEVSLPSGLEELLDRSKSYWIQMSKKWRQDSDSQSRHCVRIKTYYQKWERTISKCAELHPCICESEAFRFPDGINLN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal hFc-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a role in B-cell proliferation and differentiation.
  • 基因功能參考文獻(xiàn)：
    1. CD72 appears to specifically inhibit B cell response to the endogenous TLR7 ligand Sm/RNP. PMID: 27810925
    2. CD72 negatively regulates mouse mast cell functions and down-regulates the expression of KIT and FcepsilonRIalpha. PMID: 25239131
    3. These results strongly suggest that the Cd72(c) is a crucial modifier gene that regulates Fas(lpr)-induced autoimmune disease due to its reduced activity of B cell signal regulation. PMID: 23616572
    4. Cd72 polymorphism affects susceptibility to lupus phenotypes. PMID: 23365086
    5. Inhibitory coreceptors CD72 and CD22 are responsible for setting the requirement of CD40 signaling for survival and proliferation of antigen-stimulated spleen B cells. PMID: 12902484
    6. results strongly suggest that the apoptosis preventing signal evoked by CD72 ligation is delivered through the pathway of NF-kappaB, c-Myc, p27(Kip1) and cyclin PMID: 14734859
    7. Strength of B-cell antigen receptor signals is strictly tuned by the interaction of CD100 with CD72; this interaction is essential for maintaining immunological homeostasis as well as generating a proper immune response. PMID: 16113236
    8. CD72 plays a dominant role as a negative regulator of BCR signaling in primary mature B lymphocytes. PMID: 16621999
    9. CD72 is required to maintain B cell anergy and functions as a regulator of peripheral B cell tolerance PMID: 18821699
    10. CD72 is an inhibitory receptor on NK cells regulating cytokine production. PMID: 19197938
    11. CD72 activates extracellular signal-regulated kinase and c-Jun N-terminal kinase (but not p38 mitogen-activated protein kinase), synergizing with B cell receptor signals to induce proliferation of B cells in X-linked immunodeficiency. PMID: 11466342

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Pre-B-cells and B-cells but not terminally differentiated plasma cells.
  • 數(shù)據(jù)庫鏈接：