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  4. Recombinant Mouse Breakpoint cluster region protein (Bcr), partial

Recombinant Mouse Breakpoint cluster region protein (Bcr), partial

  • 中文名稱：
    Recombinant Mouse Breakpoint cluster region protein(Bcr) ,partial
  • 貨號：
    CSB-YP750838MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Breakpoint cluster region protein(Bcr) ,partial
  • 貨號：
    CSB-EP750838MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Breakpoint cluster region protein(Bcr) ,partial
  • 貨號：
    CSB-EP750838MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Breakpoint cluster region protein(Bcr) ,partial
  • 貨號：
    CSB-BP750838MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Breakpoint cluster region protein(Bcr) ,partial
  • 貨號：
    CSB-MP750838MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Bcr; Kiaa3017Breakpoint cluster region protein; EC 2.7.11.1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein (GAP) domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form. The amino terminus contains an intrinsic kinase activity. Functions as an important negative regulator of neuronal RAC1 activity. Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity. Plays a major role as a RHOA GEF in keratinocytes being involved in focal adhesion formation and keratinocyte differentiation.
  • 基因功能參考文獻(xiàn)：
    1. BCR signaling elicits maximal cell death through upregulation of multiple BH3-only proteins; namely Bim, Bik, and Noxa. PMID: 26184912
    2. The resistance in BCR-ABL1 cells resulted either from the Y253H mutation in the BCR-ABL1 gene or incubation in increasing concentrations of imatinib. PMID: 26251899
    3. PDZK1 has novel SR-BI-independent function in VSM that affords protection from neointima formation, and this involves PDZK1 suppression of VSM cell proliferation via an inhibitory interaction with Bcr PMID: 25886360
    4. Hap1 interacts with Bcr on microtubules to regulate neuronal differentiation. PMID: 25671650
    5. Grb10 is involved in BCR-ABL-positive leukemia in mice. PMID: 25249015
    6. Bcr is an integral member of the Par-Tiam1 complex that controls polarized cell migration by locally restricting both Rac1 and PKCzeta function. PMID: 24152735
    7. Loss of Bcr expression causes defects in spine development. PMID: 24960694
    8. Suggest that HS-438 may be a novel drug candidate with the therapeutic potential to target BCR-ABL and overcome imatinib resistance in patients with chronic myeloid leukemia. PMID: 24657654
    9. IRF8-rescued BCR-ABL-expressing dendritic cells were capable of inducing CTLs more efficiently than control dendritic cells. PMID: 24242069
    10. study provided evidence for a novel, BCR-ABL-mediated antiapoptotic mechanism, which results from the increased acetylation of p53 at the K317/K320 residue, thus preventing the nuclear export of p53 in response to DNA damage. PMID: 22696202
    11. Intrafemoral transplantation of BCR-ABL-transduced Cbl-b(-/-) cells revealed equivalent latency of disease development to the wild-type transplants PMID: 23160449
    12. Data show that T315I-mutated BCR-ABL is functional at the stem cell level, conferring to murine embryonic stem cell (mESC)-derived leukemic cells a long-term hematopoietic repopulation ability. PMID: 23287417
    13. BCR is a novel substrate of PTPRT . PMID: 22767509
    14. BCR signalling as a mechanism to cause biased cellular and Ig repertoire selection, ultimately contributing to B cell-mediated autoimmune predisposition. PMID: 22728826
    15. Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice. PMID: 22408137
    16. BCR-JAK2 codes for a protein containing the BCR oligomerization domain fused to the JAK2 tyrosine-kinase domain PMID: 22384256
    17. STAT5a/b is essential for the induction of CML-like leukemia by BCR-ABL1 and of polycythemia by JAK2(V617F). PMID: 22234689
    18. The data confirm that BCR-ABL promotes ROS and demonstrate that NF-kappaB prevents excessive levels. PMID: 21625221
    19. CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis PMID: 21900237
    20. Study shows that an intramolecular interaction between the SH2 and kinase domains in Bcr-Abl is both necessary and sufficient for high catalytic activity of the enzyme. PMID: 22000011
    21. (18)F-SKI696 is taken up in vivo by tumors that overexpress Bcr-Abl PMID: 21764785
    22. Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia. PMID: 21263154
    23. The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells.[Bcr-Abl] PMID: 18813851
    24. Id2 deficient mice in a C57BL/6 genetic background exhibit increased cellularity in the granulocyte/myeloid progenitor compartment and show significantly higher numbers of maturing neutrophils.[Bcr-Abl] PMID: 18725623
    25. BCR-mediated regulation of recombination-activating gene expression is additively controlled in B cells by the extracellular signal-regulated MAP kinase and phosphatidylinositol 3-kinase pathways, in ligand-dependent and ligand-independent manners. PMID: 20709952
    26. a BCR-ABL mutant lacking direct binding sites for the GRB2, CBL and CRKL adapter proteins fails to induce leukemia in mice PMID: 19823681
    27. A mouse model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9 PMID: 12032333
    28. These findings suggest that Bim plays an important role in the apoptosis of early hematopoietic progenitors and that Bcr-Abl supports cell survival in part through downregulation of this cell death activator. PMID: 15226421
    29. suppression of normal hematopoiesis in BCR-ABL-induced leukemia is an active process involving secretion of the cell death-inducing factor 24p3 by mouse leukemia cells PMID: 15735695
    30. in mature B cells, BCR stimulation induces a short lived unfolded protein response similar to the LPS-triggered nonclassical UPR, but does not induce plasma cell differentiation PMID: 16188879
    31. BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells PMID: 16297667
    32. BCR-ABL-expressing leukemic stem cells depend to a greater extent on CD44 for homing and engraftment than do normal hematopoietic stem cells PMID: 16998483
    33. Coexpression with the bcr-1 isoform of PML-RARalpha did not increase the penetrance of APL The bcr-1 and bcr-3 isoforms of RARalpha-PML, therefore, have different biological activities that may be relevant for the pathogenesis of murine APL. PMID: 17008533
    34. BCR/ABL repressed CCL9 expression at the transcriptional level PMID: 17160016
    35. Bcr-Abl oncoprotein requires the IL-3 receptor/Jak2/Stat5 pathways for oncogenic transformation of NIH 3T3 fibroblasts. PMID: 18071309
    36. cells treatment-induced BCR-ABL mutations conferring broad resistance to kinase inhibitor were able to spread resistance to non-mutated cells through overexpression of interleukin 3, activation of MEK/ERK and JAK2/STAT5 pathways, and downregulation of Bim PMID: 18216868
    37. BCR-ABL impairs host defenses and promotes malignant transformation, involving dual suppression of IFN-activated signaling pathways PMID: 18287094
    38. The interaction of beta1-integrin and extracellular matrix components is functionally important in leukemic cells expressing high-levels of BCR/ABL. PMID: 18313694
    39. T315I mutant form of BCR-ABL is associated with leukemia PMID: 18429956
    40. Expression of miR-203 reduces ABL1 and BCR-ABL1 fusion protein levels and inhibits tumor cell proliferation in an ABL1-dependent manner, suggesting it may function as a tumor suppressor. PMID: 18538733
    41. BCR-ABL leukemogenesis inis blocked by PI3K in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells PMID: 18704194
    42. FcgammaRIIB coaggregation dampens BCR-induced BLyS receptor up-regulation PMID: 18791164
    43. Intimal proliferation in low-flow carotid arteries is decreased in Bcr knockout mice compared with wild-type mice, suggesting the critical role of Bcr kinase in VSMC proliferation in vivo, by regulating PPARgamma/nuclear factor kappaB. PMID: 19023129
    44. BCR-ABL promotes the frequency of mutagenic single-strand annealing DNA repair PMID: 19571320

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  • 亞細(xì)胞定位：
    Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Cell projection, axon. Cell junction, synapse.
  • 組織特異性：
    Expressed in brain. In hippocampal subregions, most abundant in the CA1 region and expressed at successively lower levels in the dentate gyrus and the CA3 region.
  • 數(shù)據(jù)庫鏈接：