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  4. Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 23 (Adam23), partial

Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 23 (Adam23), partial

  • 中文名稱：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 23(Adam23),partial
  • 貨號(hào)：
    CSB-YP870825MO
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 23(Adam23),partial
  • 貨號(hào)：
    CSB-EP870825MO
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 23(Adam23),partial
  • 貨號(hào)：
    CSB-EP870825MO-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 23(Adam23),partial
  • 貨號(hào)：
    CSB-BP870825MO
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 23(Adam23),partial
  • 貨號(hào)：
    CSB-MP870825MO
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Adam23
  • Uniprot No.：
  • 別名：
    Adam23; Mdc3Disintegrin and metalloproteinase domain-containing protein 23; ADAM 23; Metalloproteinase-like; disintegrin-like; and cysteine-rich protein 3; MDC-3
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.
  • 基因功能參考文獻(xiàn)：
    1. ADAM23 expression on DCs partially governs antigen-presentation capacities to responder CD4(+) T cells. Knockdown did not alter the maturation profile of DCs but impaired cognate T cell responses, decreased antigen-specific clonal expansion, and decreased Th cytokine production. Targeting the alpha(v)beta(3) integrin receptors resulted in similar phenotypes indicating their role in the ADAM23 response. PMID: 27317750
    2. Adam23 knockdown up-regulates P27KIP1 in P19/ADAM23 knockdown cells, one reason that P19/ADAM23 knockdown cells can differentiate into neurons without retinoic acid induction. PMID: 22973984
    3. Data suggest that leucine-rich glioma inactivated 3 (LGI3) may be a candidate adipokine that is perturbed in obesity and suppresses adipogenesis through its receptor, ADAM23. PMID: 22405860
    4. Data suggest that LGI1 binding to ADAM23 is necessary to correctly pattern neuronal morphology, and altered anatomical patterning contributes to autosomal dominant partial epilepsy with auditory features. PMID: 19796686
    5. These results suggest ADAM23 may play roles in both early and later stage of neuronal differentiation. PMID: 17333391
    6. PrP(C) is a novel molecular partner for ADAM23 in the nervous systems. PMID: 19477226
    7. Functional role of ADAM23 during lung cancer metastatic progression by negatively modulating alpha(v)beta(3) integrin activation. PMID: 19549921

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.; [Isoform Gamma]: Secreted.
  • 組織特異性：
    Brain specific.
  • 數(shù)據(jù)庫(kù)鏈接：