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  4. Recombinant Mouse Espin (Espn), partial

Recombinant Mouse Espin (Espn), partial

  • 中文名稱：
    小鼠Espn重組蛋白
  • 貨號：
    CSB-YP007827MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Espn重組蛋白
  • 貨號：
    CSB-EP007827MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Espn重組蛋白
  • 貨號：
    CSB-EP007827MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Espn重組蛋白
  • 貨號：
    CSB-BP007827MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Espn重組蛋白
  • 貨號：
    CSB-MP007827MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Espn
  • Uniprot No.：
  • 別名：
    Espn; Espin; Ectoplasmic specialization protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimension, dynamics and signaling capacities of the actin filament-rich microvilli in the mechanosensory and chemosensory cells. Required for the assembly and stabilization of the stereociliary parallel actin bundles. Plays a crucial role in the formation and maintenance of inner ear hair cell stereocilia. Involved in the elongation of actin in stereocilia. In extrastriolar hair cells, required for targeting MYO3B to stereocilia tips, and for regulation of stereocilia diameter and staircase formation.
  • 基因功能參考文獻：
    1. Findings suggest that Lhx1/5, through regulating Espin protein expression, control dendritogenesis and spine morphogenesis in postnatal Purkinje cells (PCs). PMID: 28516904
    2. We demonstrated for the first time that espin regulates both anchorage-dependent growth and anchorage-independent growth in melanoma cells through G1 arrest and modulates the expression and/or activity of p21Cip1, p27Kip1, Erk, and Akt. PMID: 24936833
    3. When myosin IIIB (MYO3B) is coexpressed with espin-1 (ESPN1), MYO3B targets and carries ESPN1 to COS7 cell filopodia tips. This tip localization is lost when the ESPN1 C terminus actin-binding site is removed. PMID: 22264607
    4. espin actin-bundling proteins are required for the assembly and stabilization of the stereociliary parallel actin bundle. PMID: 21455486
    5. Genetic and physical maps of jerker (Espn(je)) on mouse chromosome 4 PMID: 12207892
    6. Data show that espin actin-bundling proteins, which are the target of the jerker deafness mutation, caused a dramatic, concentration-dependent lengthening of LLC-PK1-CL4 cell microvilli and their parallel actin bundles. PMID: 14657236

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cell projection, stereocilium. Cell projection, microvillus. Cell junction.; [Isoform 2]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; [Isoform 3]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; [Isoform 4]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; [Isoform 5]: Cytoplasm, cytoskeleton. Cell projection, dendritic spine.; [Isoform 8]: Cytoplasm, cytoskeleton. Cell junction. Note=Isoform 8 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids.
  • 組織特異性：
    Expressed at high concentration in the microvillar parallel actin bundle (PAB) of hair cells stereocilia in the cochlea and vestibular system. Detected also at high levels of a number of other sensory cell types, including taste receptor cells, solitary c
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