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  4. Recombinant Mouse Histone-lysine N-methyltransferase ASH1L (Ash1l), partial

Recombinant Mouse Histone-lysine N-methyltransferase ASH1L (Ash1l), partial

  • 中文名稱：
    Recombinant Mouse Histone-lysine N-methyltransferase ASH1L(Ash1l) ,partial
  • 貨號：
    CSB-YP858773MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Histone-lysine N-methyltransferase ASH1L(Ash1l) ,partial
  • 貨號：
    CSB-EP858773MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Histone-lysine N-methyltransferase ASH1L(Ash1l) ,partial
  • 貨號：
    CSB-EP858773MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Histone-lysine N-methyltransferase ASH1L(Ash1l) ,partial
  • 貨號：
    CSB-BP858773MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Histone-lysine N-methyltransferase ASH1L(Ash1l) ,partial
  • 貨號：
    CSB-MP858773MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ash1l
  • Uniprot No.：
  • 別名：
    Ash1lHistone-lysine N-methyltransferase ASH1L; EC 2.1.1.-; EC 2.1.1.359; ASH1-like protein; Absent small and homeotic disks protein 1 homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Histone methyltransferase specifically trimethylating 'Lys-36' of histone H3 forming H3K36me3. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear.
  • 基因功能參考文獻：
    1. Loss of Ash1l leads to more proliferative keratinocytes in disturbed differentiation stages and Ash1l mutation leads to delayed re-epithlialization but increased keratinocyte proliferation at the wound edge. PMID: 28374742
    2. Results reveal that a novel process of activity-dependent transcriptional repression exists in neurons and that Ash1L mediates the long-term repression of nrxn1alpha, thus implicating an important role for epigenetic modification in brain functioning. PMID: 27229316
    3. Histone Methyltransferase Ash1l Is a Target of miR-291 and Regulates Hox Gene Expression. PMID: 26549848
    4. important for the development and function of reproductive tissues and for proper expression of homeotic genes PMID: 26333994
    5. Ash1l is a novel key regulator of changes associated with the adaptation of HSCs to the BM niche at the fetal to adult transition or upon transplantation of HSCs into an adult recipient. PMID: 25866973
    6. Ash1l-mediated H3K4 methylation at the Tnfaip3 promoter is required for controlling innate IL-6 production and suppressing inflammatory autoimmune diseases, providing mechanistic insight into epigenetic modulation of immune responses and inflammation PMID: 24012418
    7. ASH1 mono- or di-methylates histone H3 K36 but not any other lysine residues of recombinant unmodified mammalian histones PMID: 17544230
    8. the C-terminal part of ASH1 interacts with HDAC1 repression complexes, suggesting that the PHD finger of ASH1 may be involved in down-regulation of genes for normal development of alphabeta T cells. PMID: 17981149

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  • 亞細胞定位：
    Nucleus. Cell junction, tight junction. Chromosome.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily
  • 數(shù)據(jù)庫鏈接：