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  4. Recombinant Mouse Interleukin-31 receptor subunit alpha (Il31ra), partial

Recombinant Mouse Interleukin-31 receptor subunit alpha (Il31ra), partial

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  • 中文名稱：
    小鼠Il31ra重組蛋白
  • 貨號：
    CSB-EP818362MO
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP818362MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Il31ra.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP818362MO could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Il31ra.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Il31ra; GlmrInterleukin-31 receptor subunit alpha; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; GLM-R; mGLM-R; Gp130-like monocyte receptor; Gp130-like receptor; Novel cytokine receptor 10; NR10; ZcytoR17
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Extracellular Domain
  • 來源：
    E.coli
  • 分子量：
    59.2 kDa
  • 表達(dá)區(qū)域：
    19-499aa
  • 氨基酸序列
    VLPTKPENISCVFYFDRNLTCTWRPEKETNDTSYIVTLTYSYGKSNYSDNATEASYSFPRSCAMPPDICSVEVQAQNGDGKVKSDITYWHLISIAKTEPPIILSVNPICNRMFQIQWKPREKTRGFPLVCMLRFRTVNSSHWTEVNFENCKQVCNLTGLQAFTEYVLALRFRFNDSRYWSKWSKEETRVTMEEVPHVLDLWRILEPADMNGDRKVRLLWKKARGAPVLEKTFGYHIQYFAENSTNLTEINNITTQQYELLLMSQAHSVSVTSFNSLGKSQEAILRIPDVHEKTFQYIKSMKAYIAEPLLVVNWQSSIPAVDTWIVEWLPEAAMSKFPALSWESVSQVTNWTIEQDKLKPFTCYNISVYPVLGHRVGEPYSIQAYAKEGTPLKGPETRVENIGLRTATITWKEIPKSARNGFINNYTVFYQAEGGKELSKTVNSHALQCDLESLTRRTSYTVWVMASTRAGGTNGVRINFKT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Tris-based buffer，50% glycerol
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：

    The production of this recombinant Mouse Il31ra protein is just like all recombinant proteins. The process involved transfecting E.coli cells with DNA vector containing the template of recombinant DNA. The E.coli cells containing the template were then cultured so that they could transcribe and translate the Il31ra protein. N-terminal 6xHis tag was used in the process. The purity is 0.85 determined by SDS-PAGE.

    The receptor IL-31RA is the receptor of IL-31, which has been found unregulated in skin and lung fibroblasts from Scleroderma. IL-31 acts via a heterodimeric receptor comprising IL-31RA and oncostatin M, expressed by multiple cell types, and signalling via PI3K, ERK and JAK/STAT pathways. Interleukin (IL)-31 is a cytokine produced mainly by Th2 cells. And it signals via the IL-31RA and oncostatin M receptor β heterodimer. IL-31RA is expressed in both human skin and dorsal root ganglions. IL-31RA is a critical neuroimmune link between Th2 cells and the sensory nerves. Some resports suggested that that IL-31RA is expressed not only in nerve fibres but also in keratinocytes in the dermis from Alzheimer patients. Besides, researchers observed that administration of IL-31 upregulates IL-31RA in dorsal root ganglia and causes severe itch-associated scratching behaviour in mice.

  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
  • 基因功能參考文獻(xiàn)：
    1. Anti-IL-31 receptor antibody is shown to be a potential therapeutic option for treating itch and dermatitis in mice PMID: 24946165
    2. IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch. PMID: 24373353
    3. Gp130(757F/F) mice rapidly develop distal stomach tumors, with loss of SHP2/Erk/AP-1 transcriptional regulation exemplified by decreased TFF1 expression and increased STAT1/3 regulated genes such as Reg I. PMID: 14699500
    4. IL-31 receptor alpha signaling is a novel negative regulatory pathway that specifically limits T helper cell type 2 inflammation. PMID: 17353366
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 組織特異性：
    Expressed in a subset of dorsal root ganglia neurons. Expressed in spinal cord and trigeminal ganglion (at protein level). Expressed in skin, testis, bone marrow and thymus.
  • 數(shù)據(jù)庫鏈接：