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  4. Recombinant Mouse Kunitz-type protease inhibitor 1 (Spint1)

Recombinant Mouse Kunitz-type protease inhibitor 1 (Spint1)

  • 中文名稱：
    小鼠Spint1重組蛋白
  • 貨號：
    CSB-YP870801MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Spint1重組蛋白
  • 貨號：
    CSB-EP870801MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Spint1重組蛋白
  • 貨號：
    CSB-EP870801MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Spint1重組蛋白
  • 貨號：
    CSB-BP870801MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Spint1重組蛋白
  • 貨號：
    CSB-MP870801MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Spint1
  • Uniprot No.：
  • 別名：
    Spint1; Hai1; Kunitz-type protease inhibitor 1; Hepatocyte growth factor activator inhibitor type 1; HAI-1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    30-507
  • 氨基酸序列
    E LPSAPAELPG GAACLSRFTS GVPSFVLDTE ASVSNGATFL GSPTARRGWD CVRSCCTTQN CNLALVELQP DGGEDAISAC FLMNCLYEQN FVCKFAPKEG FINYLTQELY RSYRELRTRG FGGSRIPRIW MGIDLKVQLQ KPLVLNEADN TDWHLLQGDS DVRVERKRPE EVELWGLKEG TYLFQLTRTD SDQPEETANL TITVLTAKQT EDYCLASYKV GRCRGSFPRW YYDPKEQICK SFTFGGCLGN KNNYLREEEC MLACKDVQGI SPKRHHPVCS GSCHATQFRC SNGCCIDGFL ECDDTPDCPD GSDEATCEKY TSGFDELQNI HFLSDKGYCA ELPDTGFCKE NIPRWYYNPF SERCARFTYG GCYGNKNNFE EEQQCLESCR GISKKDVFGL RREGSIPTVG SAEVAIAVFL VICIIVVLTI LGYCFFKNQR KEFHSPLHHP PPTPASSTVS TTEDTEHLVY NHTTQPL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Inhibitor of HGF activator.
  • 基因功能參考文獻：
    1. Results suggest that insufficient hepatocyte growth factor activator inhibitor type 1 (HAI-1) function promotes intestinal carcinogenesis by activating nuclear factor-kappaB (NF-kappaB) signaling. PMID: 27612426
    2. By completing our structural characterization of the previously unknown N-terminal region of HAI-1, we provide new insight into the interplay between tertiary structure and the inhibitory activity of a multidomain protease inhibitor PMID: 27189939
    3. HAI-1 may have a critical role in maintaining normal keratinocyte morphology through regulation of PAR-2-dependent p38 mitogen-activated protein kinase signaling. PMID: 25842366
    4. HAI-1 regulates the activity of activated matriptase, whereas HAI-2 has an essential role in regulating prostasin-dependent matriptase zymogen activation. PMID: 24962579
    5. HAI-1 and HAI-2 influence proliferation and cell fate of NPCs and their expression levels are linked to BMP sign PMID: 23409135
    6. HAI-1/SPINT1 has a crucial role in suppressing intestinal tumorigenesis, which implies a novel link between epithelial cell surface serine protease inhibitors and protection from carcinogenic stimuli. PMID: 23447577
    7. mutations in Prss8 restored placentation and normal development of HAI-1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in HAI-2-deficient embryos. PMID: 22952456
    8. HAI-1 has a crucial suppressive role in oral squamous cell carcinoma cells' invasiveness. PMID: 22262311
    9. HAI-1 and -2 are overexpressed in the liver in cholangiopathies with ductular reactions and are possibly involved in liver fibrosis and hepatic differentiation. PMID: 21898507
    10. HAI-1/SPINT1 plays an important role in maintaining colonic epithelium integrity. PMID: 21840293
    11. HAI-1 is required for branching morphogenesis in the chorioallantoic placenta. PMID: 15964823
    12. Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth. PMID: 17174946
    13. HAI-1, in addition to its protease inhibitory function, plays a role in transporting matriptase as a matriptase-HAI-1 complex from the basolateral plama membrane to the apical plasma membrane PMID: 18402552
    14. Unlike HAI-1 and matriptase, HAI-2 expression is detected in non-epithelial cells of brain and lymph nodes, suggesting that HAI-2 may also be involved in inhibition of serine proteases other than matriptase PMID: 18713750
    15. These findings indicate that Hai-1/Spint1 has critical roles in the regulated keratinization of the epidermis and hair development. PMID: 18832587
    16. This study identifies matriptase suppression as an essential function of HAI-1 in postnatal tissue homeostasis. PMID: 19389929

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  • 亞細胞定位：
    Secreted.
  • 數(shù)據(jù)庫鏈接：