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  4. Recombinant Mouse Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Aadat)

Recombinant Mouse Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial (Aadat)

  • 中文名稱：
    Recombinant Mouse Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Aadat)
  • 貨號：
    CSB-YP894845MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Aadat)
  • 貨號：
    CSB-EP894845MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Aadat)
  • 貨號：
    CSB-EP894845MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Aadat)
  • 貨號：
    CSB-BP894845MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Aadat)
  • 貨號：
    CSB-MP894845MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Aadat
  • Uniprot No.：
  • 別名：
    Aadat; Kat2Kynurenine/alpha-aminoadipate aminotransferase; mitochondrial; KAT/AadAT; 2-aminoadipate aminotransferase; 2-aminoadipate transaminase; EC 2.6.1.39; Alpha-aminoadipate aminotransferase; AadAT; Kynurenine aminotransferase II; Kynurenine--oxoglutarate aminotransferase II; Kynurenine--oxoglutarate transaminase 2; EC 2.6.1.7; Kynurenine--oxoglutarate transaminase II
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    30-425
  • 氨基酸序列
    P KTLISLAPGS PNPSMFPFKS AAFTVENGST IRFEDDLIKR ALQYSPSYGI PELLSWLKQF QVKLHNPPTV NYPPNQGQMD LCITSGCQDG LCKAFEMLIN PGDTILVNEP LFPGTLYAMK PLGCNIINVP SDEHGIIPEG LKKILSQWKP EDSKDPTKKT PKFLYTVPNG NNPTGNSLTG DRKKEIYELA RKYDFLIIED DPYYFLQFSK PWEPTFLSMD VDGRVIRADT FSKTVSSGLR VGFMTGPKTL IQNIVLHTQV SSVHACTLSQ LMILQLLHQW GEEGFLAHID RTIDFYKNQR DSILAAADKW LRGLAEWHVP KAGMFLWIKV KGISDTKQLI EEKAIEREVL LVPGNGFFID GSAPTSFFRA SFSLATPAQM DTAFQRLAQL IKESL
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
  • 基因功能參考文獻(xiàn)：
    1. This study demonstrates the presence of kynurenine aminotransferase-2 mRNA and protein throughout the adult C57Bl6 mouse brain PMID: 27568378
    2. human KAT III/CCBL2 possesses cysteine S-conjugate beta-lyase activity, as does mouse KAT II PMID: 25231977
    3. This study showed that KAT II KO mice show the expected decrease in extracellular kynurenic acid levels, and that this reduction is accompanied by a significant increase in extracellular glutamate. PMID: 20336058
    4. The activity of mouse KAT II was not significantly inhibited by any proteinogenic amino acids at equimolar concentrations and half-life was 27.4 minutes at 65 degree C. PMID: 20482848
    5. Alpha7* nAChR and NMDA receptor functions were studied in kynurenine aminotransferase II null mice(mKat-2-/- mice). At 21 postnatal days, mKat-2-/- mice had lower hippocampal kynurenic acid levels and more spontaneous locomotor activity than control mice PMID: 15140935
    6. Results show that gene targeting of kynurenine aminotransferase II (KAT) in mice leads to early and transitory decreases in brain KAT activity and kynurenic acid levels with commensurate behavioral and neuropathological changes. PMID: 15282294

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  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    Class-I pyridoxal-phosphate-dependent aminotransferase family
  • 組織特異性：
    Expressed mainly in kidney and to a lesser amount in liver and brain.
  • 數(shù)據(jù)庫鏈接：