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  4. Recombinant Mouse Lysine-specific demethylase PHF2 (Phf2), partial

Recombinant Mouse Lysine-specific demethylase PHF2 (Phf2), partial

  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-YP895738MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-EP895738MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-EP895738MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-BP895738MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Phf2重組蛋白
  • 貨號：
    CSB-MP895738MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Phf2
  • Uniprot No.：
  • 別名：
    Phf2; Kiaa0662; Lysine-specific demethylase PHF2; EC 1.14.11.-; GRC5; PHD finger protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.
  • 基因功能參考文獻(xiàn)：
    1. The paper's findings establish a downstream epigenetic checkpoint, whereby Phf2, through facilitating H3K9me2 demethylation at specific gene promoters, protects liver from the pathogenesis progression of Non-alcoholic Fatty Liver Disease. PMID: 29844386
    2. these results demonstrate that PHF2 histone demethylase controls adipogenic gene expression during differentiation. PMID: 25266703
    3. PHF2 enhances osteoblast differentiation by demethylating Runx2, while suppressor of variegation 3-9 homolog 1 (SUV39H1) inhibits bone formation by methylating it. PMID: 25257467
    4. Arid5b recruits Phf2 to the promoter region of Sox9 target genes and stimulates H3K9me2 demethylation of these genes. PMID: 24276541
    5. Data from PHF2 knockout mice suggest that PHF2 plays roles in both adipogenesis and neonatal growth/weight gain; PHF2 interacts with promoter region of CEBPA (CCAAT-enhancer binding protein alpha) gene and demethylates histones in chromatin. PMID: 23274892
    6. histone H3K4 trimethylation by a homeodomain of PHF2 modulates histone demethylation PMID: 20129925

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  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Chromosome, centromere, kinetochore.
  • 蛋白家族：
    JHDM1 histone demethylase family, JHDM1D subfamily
  • 數(shù)據(jù)庫鏈接：