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  4. Recombinant Mouse Meteorin-like protein (Metrnl)

Recombinant Mouse Meteorin-like protein (Metrnl)

In Stock
  • 中文名稱：
    小鼠Metrnl重組蛋白
  • 貨號：
    CSB-EP855340MO
  • 規(guī)格：
    ￥1836
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    Metrnl
  • Uniprot No.：
  • 別名：
    MetrnlMeteorin-like protein; Subfatin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 來源：
    E.coli
  • 分子量：
    33.9kDa
  • 表達區(qū)域：
    46-311aa
  • 氨基酸序列
    QYSSDLCSWKGSGLTREARSKEVEQVYLRCSAGSVEWMYPTGALIVNLRPNTFSPAQNLTVCIKPFRDSSGANIYLEKTGELRLLVRDIRGEPGQVQCFSLEQGGLFVEATPQQDISRRTTGFQYELMSGQRGLDLHVLSAPCRPCSDTEVLLAICTSDFVVRGFIEDVTHVPEQQVSVIYLRVNRLHRQKSRVFQPAPEDSGHWLGHVTTLLQCGVRPGHGEFLFTGHVHFGEAQLGCAPRFSDFQRMYRKAEEMGINPCEINME
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 6xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

平均分:
5.0分 - 1 個評價

實驗應用：細胞實驗

產品評價： 使用Recombinant Mouse Meteorin-like protein (Metrnl)進行細胞干預實驗，隨后進行western blot實驗，發(fā)現Metrnl干預組metrnl蛋白表達量明顯增加，且相應目前蛋白表達有趨勢，效果良好

By 顏老師

靶點詳情

  • 功能：
    Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
  • 基因功能參考文獻：
    1. Exercise-induced muscle Metrnl effectively reduces fat accumulation. PMID: 29854769
    2. The results of this study suggest that regular exercise is indispensable to reduce body weight and fat mass through upregulation of the muscle energy-sensing network and Metrnl protein levels, and retraining with dietary change is necessary to obtain the retraining effects more quickly. PMID: 29703203
    3. Data (including data from studies in transgenic/knockout mice and 3T3-L1 cells) suggest expression of Metrnl in white adipocytes controls insulin sensitivity via activation of PPARg (peroxisome proliferator activated receptor gamma) signaling pathway. PMID: 26307585
    4. Metrnl represents a novel cytokine, which is likely involved in both innate and acquired immune responses. PMID: 25486603
    5. Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin PMID: 24393292
    6. Study reports the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure; increasing circulating levels of Metrnl stimulates energy expenditure and improves glucose tolerance and the expression of genes associated with beige fat thermogenesis and anti-inflammatory cytokines. PMID: 24906147
    7. Cometin is a novel neurotrophic factor(meteorin protein family) that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo. PMID: 21985865

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Meteorin family
  • 組織特異性：
    Highly expressed in subcutaneous adipose tissue.
  • 數據庫鏈接：

    KEGG: mmu:210029

    UniGene: Mm.153566