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  4. Mouse Meteorin-like protein(METRNL) ELISA kit

Mouse Meteorin-like protein(METRNL) ELISA kit

  • 中文名稱：
    小鼠鎳紋樣蛋白(METRNL)酶聯(lián)免疫試劑盒
  • 貨號：
    CSB-EL013718MO
  • 規(guī)格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    小鼠鎳紋樣蛋白(METRNL)酶聯(lián)免疫試劑盒（CSB-EL013718MO）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿樣本中的METRNL含量。METRNL是一種分泌蛋白，具有多種生物學功能。其在治療內(nèi)皮功能受損、神經(jīng)系統(tǒng)疾病、癌癥等方面具有潛在應(yīng)用價值。研究機制涉及調(diào)節(jié)內(nèi)皮細胞增殖、神經(jīng)元保護和促進神經(jīng)再生等。METRNL可能通過影響線粒體功能、代謝途徑和信號通路等發(fā)揮作用。試劑盒檢測范圍為0.06 ng/ml- 50 ng/ml，適用于研究小鼠模型在代謝調(diào)控、脂肪組織發(fā)育、糖尿病或慢性炎癥疾病中METRNL的動態(tài)表達，為探索其生理功能及分子機制提供可靠工具。本品僅用于科研，不用于臨床診斷，產(chǎn)品具體參數(shù)及操作步驟詳見產(chǎn)品說明書。
  • 別名：
    MetrnlMeteorin-like protein ELISA Kit; Subfatin ELISA Kit
  • 縮寫：
    METRNL
  • Uniprot No.：
  • 種屬：
    Mus musculus (Mouse)
  • 樣本類型：
    serum, plasma, tissue homogenates
  • 檢測范圍：
    0.06 ng/ml - 50 ng/ml
  • 靈敏度：
    0.06 ng/ml
  • 反應(yīng)時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領(lǐng)域：
    Cell Biology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%

    Three samples of known concentration were tested twenty times on one plate to assess.

    Inter-assay Precision (Precision between assays): CV%<10%

    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of mouse METRNL in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

    　

    Sample

    Serum(n=4)

    1:1

    Average %

    98

    Range %

    91-105

    1:2

    Average %

    102

    Range %

    95-109

    1:4

    Average %

    90

    Range %

    86-96

    1:8

    Average %

    89

    Range %

    82-96

  • 回收率：

    The recovery of mouse METRNL spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.

    Sample Type

    Average % Recovery

    Range

    Serum (n=5)

    101

    96-107

    EDTA plasma (n=4)

    96

    89-102

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

    ng/ml

    OD1

    OD2

    Average

    Corrected

    50

    2.434

    2.534

    2.484

    2.358

    16.6

    1.676

    1.667

    1.671

    1.546

    5.5

    0.836

    0.818

    0.827

    0.701

    1.85

    0.397

    0.419

    0.408

    0.282

    0.6

    0.221

    0.231

    0.226

    0.100

    0.2

    0.177

    0.169

    0.173

    0.047

    0.06

    0.155

    0.150

    0.153

    0.027

    0

    0.126

    0.125

    0.126

    　

  • 數(shù)據(jù)處理：
  • 貨期：
    3-5 working days

產(chǎn)品評價

靶點詳情

  • 功能：
    Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
  • 基因功能參考文獻：
    1. Exercise-induced muscle Metrnl effectively reduces fat accumulation. PMID: 29854769
    2. The results of this study suggest that regular exercise is indispensable to reduce body weight and fat mass through upregulation of the muscle energy-sensing network and Metrnl protein levels, and retraining with dietary change is necessary to obtain the retraining effects more quickly. PMID: 29703203
    3. Data (including data from studies in transgenic/knockout mice and 3T3-L1 cells) suggest expression of Metrnl in white adipocytes controls insulin sensitivity via activation of PPARg (peroxisome proliferator activated receptor gamma) signaling pathway. PMID: 26307585
    4. Metrnl represents a novel cytokine, which is likely involved in both innate and acquired immune responses. PMID: 25486603
    5. Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin PMID: 24393292
    6. Study reports the identification of meteorin-like (Metrnl), a circulating factor that is induced in muscle after exercise and in adipose tissue upon cold exposure; increasing circulating levels of Metrnl stimulates energy expenditure and improves glucose tolerance and the expression of genes associated with beige fat thermogenesis and anti-inflammatory cytokines. PMID: 24906147
    7. Cometin is a novel neurotrophic factor(meteorin protein family) that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo. PMID: 21985865

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Meteorin family
  • 組織特異性：
    Highly expressed in subcutaneous adipose tissue.
  • 數(shù)據(jù)庫鏈接：

    KEGG: mmu:210029

    UniGene: Mm.153566