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  4. Recombinant Mouse Myocardin (Myocd), partial

Recombinant Mouse Myocardin (Myocd), partial

  • 中文名稱：
    小鼠Myocd重組蛋白
  • 貨號(hào)：
    CSB-YP015357MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Myocd重組蛋白
  • 貨號(hào)：
    CSB-EP015357MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Myocd重組蛋白
  • 貨號(hào)：
    CSB-EP015357MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Myocd重組蛋白
  • 貨號(hào)：
    CSB-BP015357MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Myocd重組蛋白
  • 貨號(hào)：
    CSB-MP015357MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Myocd
  • Uniprot No.：
  • 別名：
    Myocd; Bsac2; Mycd; Srfcp; Myocardin; Basic SAP coiled-coil transcription activator 2; SRF cofactor protein
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis, urinary bladder development, and differentiation of the smooth muscle cell lineage (myogenesis). Isoform 1 mediates the cardiac transcription factor MEF2C-dependent transcription. Isoform 1 and isoform 3 are more active than isoform 2 and isoform 4 in stimulating cardiac muscle promoters.
  • 基因功能參考文獻(xiàn)：
    1. Long noncoding RNAs cardiac autophagy inhibitory factor (lncRNA CAIF) regulates autophagy through controlling p53 and myocardin. PMID: 29295976
    2. TAZ and MyoC856 physically interact. SynergyTAZ and Myocardin (MyoC856), in regulating smooth muscle gene activation was observed in primary aortic vascular smooth muscle cells. PMID: 28342289
    3. two MEF2 sites in the enhancer function cooperatively due to bridging of the MEF2C-bound sites by the SAP domain-containing co-activator protein myocardin PMID: 28351867
    4. These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity. PMID: 27403897
    5. Knock down of the serum response factor (SRF), which mediates many of the effects of myocardin, decreased cavin-1 but increased caveolin-1 and -2 mRNAs. PMID: 26244347
    6. Cholesterol loading of vascular smooth muscle cells converts them to a macrophage-appearing state by downregulating the miR-143/145-myocardin axis. PMID: 25573853
    7. Our data illustrate a novel mechanism that connects MRTF-A dependent histone H3K4 methylation to HSC activation. PMID: 25109772
    8. DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 signaling and myocardin expression. PMID: 26105053
    9. Myocardin has a critical role in maintenance of vascular and visceral smooth muscle homeostasis during postnatal development PMID: 25805819
    10. Foxf2 attenuated myocardin/serum response factor signaling in smooth muscle cells through direct binding to the N-terminal region of myocardin PMID: 25631042
    11. The authors describe the of a Cre knock-in into the Myocardin locus and show that Myocardin expression marks the earliest cardiac and smooth muscle lineages. PMID: 25174608
    12. Propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease. PMID: 25614278
    13. KLF4 is a regulator of cardiac hypertrophy by modulating the expression and the activity of myocardin. PMID: 25100730
    14. Insulin potentiates TNF-alpha in inducing NF-kappaB and SRF/SRE activities. In hyperinsulinemic states, myocardin may act as a nuclear effector of insulin, promoting cardiac hypertrophy. PMID: 24855642
    15. Data indicate that Nkx2-5, Tbx5, Gata4, or Myocd alone did not induce the de novo expression of cardiac marker proteins in 10T1/2 non-myoblastic cells. PMID: 23144723
    16. Expression of myocardin-A (and TERT) promotes promyogenic gene expression in mesenchymal stem cells. PMID: 22884695
    17. Data indicate that interferon regulatory factor 8 (IRF8) inhibited smooth muscle cells (SMCs) marker gene expression through regulating serum response factor (SRF) transactivation in a myocardin-dependent manner. PMID: 24248596
    18. Overexpression of myocardin in the embryonic heart essentially recapitulated the miR-1/133a mutant phenotype at the molecular level, arresting embryonic cardiomyocytes in an immature state. PMID: 24068960
    19. Cdc7 physically and functionally interacts with Nkx2.5 to regulate Myocd promoter activity PMID: 24133205
    20. sustained Akt1-induced alphaSMA synthesis markedly decreased upon RNA silencing of SRF and myocardin. PMID: 24106278
    21. Overexpression of transcription factors MYOCD and SRF alone or in conjunction with Mesp1 and SMARCD3 enhanced the basal but necessary cardio-inducing effect of the previously reported GATA4, TBX5, and MEF2C. PMID: 23704920
    22. Foxf1 also directly binds to serum response factor (SRF) and myocardin-related transcription factors (MRTFs). PMID: 23946491
    23. Suggest that myocardin regulates vascular injury response via miR-24/miR-29a/PDGFRB pathway. PMID: 23825366
    24. These results suggest that MYOCD down-regulates GJA1 expression via miR-1 up-regulation, thereby contributing to maintenance of normal sensitivity and development of bladder capacity. PMID: 23359472
    25. Hypertension negates the activity of myocardin in vascular smooth muscle cells. PMID: 22843699
    26. Myocardin transactivated Bmp10 via binding of a serum response factor-myocardin complex to a nonconsensus CArG element in the Bmp10 promoter. A myocardin/BMP10 signaling pathway regulates cardiomyocyte proliferation & apoptosis in embryonic heart. PMID: 22996691
    27. acetylation plays a key role in modulating myocardin function in controlling cardiac and smooth muscle gene expression PMID: 23007391
    28. Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice PMID: 23103763
    29. Data shsow that atorvastatin (ATV) inhibits myocardin gene expression in vivo and in vitro, suggesting a novel mechanism for ATV inhibition of vascular contraction. PMID: 22615115
    30. Nuclear uPAR associates with myocardin, which is then recruited from the promoters of serum response factor target genes and undergoes proteasomal degradation. This mechanism contributes to adverse vascular remodeling after injury in vivo. PMID: 22075245
    31. Transforming growth factor-beta1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein. PMID: 21984848
    32. the interaction of myocardin and Tbx5 maybe involved in cardiac development and diseases PMID: 21897873
    33. novel mechanism for Smad3-mediated inhibition of Myocd in the initiation phase of SMC differentiation. PMID: 21402709
    34. Myocardin is differentially required for the development of smooth muscle cells and cardiomyocytes. PMID: 21357509
    35. Vascular smooth muscle proteasomal degradation of myocardin is required for its transcriptional activity. PMID: 21506120
    36. Induction of microRNA-1 by myocardin in smooth muscle cells inhibits cell proliferation. PMID: 21051663
    37. Myocardin may contribute to the differentiation of CXCR4(+)/PDGFRbeta(+) progenitor cells into smooth muscle cells induced by hypoxia, which leads to the muscularization of alveolar arterioles. PMID: 20484220
    38. loss- and gain-of-function studies of myocardin and Runx2/Cbfa1, revealed that upregulation of Runx2/Cbfa1, but not loss of myocardin, played a critical role in phosphate-induced SMC lineage reprogramming and calcification PMID: 20564193
    39. Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity. PMID: 20566642
    40. These results are the first to show relative expression and activities of the major myocardin isoforms across disparate species. PMID: 20385216
    41. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype. PMID: 19801679
    42. Myocardin is a critical serum response factor cofactor regulating smooth muscle cell differentiation; forced expression of myocardin activated expression of SM22 alpha, smooth muscle alpha-actin, and calponin-h1 genes in mouse ES cells PMID: 12640126
    43. findings identify myocardin as a master regulator of smooth muscle gene expression and explain how serum response factor conveys smooth muscle specificity to its target genes PMID: 12756293
    44. Regulation of cardiac growth and development by SRF and its cofactors, including myocardin. PMID: 12858529
    45. Myocardin is the only transcription factor known to be necessary and sufficient for vascular SMC differentiation PMID: 12867591
    46. The expression of myocardin A and myocardin was markedly downregulated in Nkx2.5-null mouse hearts. PMID: 14645532
    47. Myocardin contributes to angiotensin II-induced expression of smooth muscle alpha-actin via Prx-1. PMID: 15016729
    48. Myocardin knockdown or transfected mouse myocardin overexpression affected only a subset of SMC marker genes in multipotential cells, indicating that myocardin is required but not sufficient to induce SMC lineage. PMID: 15231515
    49. myocardin has a role in positive and negative regulation of smooth muscle gene expression by changes in chromatin acetylation PMID: 15601857
    50. Notch1 intracellular domain inhibits myocardin-dependent transcription om smooth muscle. PMID: 15634680

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  • 亞細(xì)胞定位：
    Nucleus speckle. Note=Nuclear, with a punctate intranuclear pattern with exclusion from nuclei.
  • 組織特異性：
    Expressed in heart, aorta, and in smooth muscle cell-containing tissues: stomach, bladder and uterus. Isoform 1 and isoform 3 are predominantly expressed in cardiac muscle whereas isoform 4 and isoform 5 are predominantly expressed in SMC-rich tissues. Is
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