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  4. Recombinant Mouse N-acylethanolamine-hydrolyzing acid amidase (Naaa)

Recombinant Mouse N-acylethanolamine-hydrolyzing acid amidase (Naaa)

  • 中文名稱：
    小鼠Naaa重組蛋白
  • 貨號：
    CSB-YP872004MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Naaa重組蛋白
  • 貨號：
    CSB-EP872004MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Naaa重組蛋白
  • 貨號：
    CSB-EP872004MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Naaa重組蛋白
  • 貨號：
    CSB-BP872004MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Naaa重組蛋白
  • 貨號：
    CSB-MP872004MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Naaa
  • Uniprot No.：
  • 別名：
    Naaa; Asahl; N-acylethanolamine-hydrolyzing acid amidase; EC 3.5.1.60; N-acylsphingosine amidohydrolase-like; ASAH-like protein) [Cleaved into: N-acylethanolamine-hydrolyzing acid amidase subunit alpha; N-acylethanolamine-hydrolyzing acid amidase subunit beta]
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    34-362
  • 氨基酸序列
    VPGTPPL FNVSLDAAPE QRWLPMLRHY DPDFLRTAVA QVIGDRVPQW VLGMVGEIVS KVESFLPQPF TDEIRSICDS LNLSLADGIL VNLAYEASAF CTSIVAQDSQ GHIYHGRNLD YPFGKILRKL TANVQFIKNG QIAFTGTTFV GYVGLWTGQS PHKFTISGDE RDKGWWWENM IAALSLGHSP ISWLIRKTLS ESESFEAAVY TLAKTPLIAD VYYIVGGTSP KEGVVITRDR GGPADIWPLD PLNGEWFRVE TNYDHWKPAP KVDDRRTPAI KALNATGQAH LNLETLFQVL SLFPVYNNYT IYTTVMSAAE PDKYLTMIRN PS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-stearoylethanolamine > N-oleoylethanolamine > N-linoleoylethanolamine > N-arachidonoylethanolamine.
  • 基因功能參考文獻：
    1. Both inhibitors reduced several markers of macrophage activation, such as mRNA expression of inflammatory mediators, as well as cytokine and prostaglandin production, with however some differences between FAAH and NAAA inhibition. Our results support an important role for inhibition of NAE hydrolysis and NAAA inhibition in particular in controlling macrophage activation, and thus inflammation. PMID: 28065729
    2. NAAA inhibition increases palmitoylethanolamide levels in the colon and reduces colon inflammation and systemic inflammation PMID: 25384424
    3. NAAA regulates peripheral pain initiation by interrupting endogenous fatty acid ethanolamide signaling at PPAR-alpha. PMID: 23218523
    4. Results suggest that N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase cooperatively degrade anandamide and other N-acylethanolamines in macrophages. PMID: 16154384
  • 亞細胞定位：
    Lysosome. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    Acid ceramidase family
  • 數(shù)據(jù)庫鏈接：