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  4. Recombinant Mouse Nuclear receptor subfamily 4 group A member 3 (Nr4a3)

Recombinant Mouse Nuclear receptor subfamily 4 group A member 3 (Nr4a3)

  • 中文名稱：
    小鼠Nr4a3重組蛋白
  • 貨號：
    CSB-YP874140MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Nr4a3重組蛋白
  • 貨號：
    CSB-EP874140MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Nr4a3重組蛋白
  • 貨號：
    CSB-EP874140MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Nr4a3重組蛋白
  • 貨號：
    CSB-BP874140MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Nr4a3重組蛋白
  • 貨號：
    CSB-MP874140MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Nr4a3; Tec; Nuclear receptor subfamily 4 group A member 3; Orphan nuclear receptor TEC; Translocated in extraskeletal chondrosarcoma
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-627
  • 氨基酸序列
    MPCVQAQYSP SPPGSTYATQ TYGSEYTTEI MNPDYTKLTM DLGSTGIMAT ATTSLPSFST FMEGYPSSCE LKPSCLYQMP PSGPRPLIKM EEGREHGYHH HHHHHHHHHH HQQQQPSIPP PSGPEDEVLP STSMYFKQSP PSTPTTPGFP PQAGALWDDE LPSAPGCIAP GPLLDPQMKA VPPMAAAARF PIFFKPSPPH PPAPSPAGGH HLGYDPTAAA ALSLPLGAAA AAGSQAAALE GHPYGLPLAK RTATLTFPPL GLTASPTASS LLGESPSLPS PPNRSSSSGE GTCAVCGDNA ACQHYGVRTC EGCKGFFKRT VQKNAKYVCL ANKNCPVDKR RRNRCQYCRF QKCLSVGMVK EVVRTDSLKG RRGRLPSKPK SPLQQEPSQP SPPSPPICMM NALVRALTDA TPRDLDYSRY CPTDQATAGT DAEHVQQFYN LLTASIDVSR SWAEKIPGFT DLPKEDQTLL IESAFLELFV LRLSIRSNTA EDKFVFCNGL VLHRLQCLRG FGEWLDSIKD FSLNLQSLNL DIQALACLSA LSMITERHGL KEPKRVEELC TKITSSLKDH QRKGQALEPS EPKVLRALVE LRKICTQGLQ RIFYLKLEDL VPPPSVIDKL FLDTLPF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes. Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site. Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression. In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A. Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development. Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription. Plays also a role in inflammation; upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site. In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation. Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP- glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle. Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface. Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration. Inhibits adipogenesis. Also participates in cardiac hypertrophy by activating PARP1.
  • 基因功能參考文獻：
    1. NOR1 deletion induced differential inflammatory gene transcription in macrophages but did not influence abdominal aortic aneurysm formation. PMID: 29047330
    2. Nor-1 expression drives multiple physiological changes/pathways that are critical to the beneficial responses of muscle to exercise. PMID: 27144290
    3. these results show that NR4A3 is involved in TLR-mediated activation and gene expression of dendritic cells PMID: 28893954
    4. Study shows that NOR-1 can transduce survival signals in neuronal cells responsible for hypoxiainduced apoptotic insults through activation of a CREB/cIAP2-dependent mechanism PMID: 26613168
    5. Nuclear receptors of the NR4a family are not required for the development and function of follicular T helper cells PMID: 25899083
    6. Promoting Liver X receptor-alpha expression inhibits lipopolysaccharide induced inflammation in Kupffer cells through elevating NOR-1 expression. PMID: 26239564
    7. Identified Nur77/Nor1 as novel regulators of thrombomodulin expression and function in vascular endothelial cells. PMID: 26634653
    8. Nr4a3 factor plays crucial role regulatory T cells, mediating the two defining characteristics of regulatory T cells: stability of cell lineage and immunosuppressive functions. PMID: 26304965
    9. Studies demonstrate that NOR1 deletion in hematopoietic stem cells accelerates atherosclerosis formation by promoting myelopoiesis in the stem cell compartment and by inducing local proatherogenic activities in the macrophage. PMID: 24806827
    10. Our data support a role for NOR-1 as a negative modulator of the acute response elicited by pro-inflammatory stimuli in the vasculature. PMID: 25536180
    11. Results indicate that DNA hypomethylation of the CpG island at Nr4a3 exon 3 is associated with low Nr4a3 expression, and correlates with poor prognosis of neuroblastoma. PMID: 24626568
    12. Skeletal muscle-specific Nor-1 expression regulates genes and pathways that regulate adiposity, muscle fiber type metabolic capacity, and endurance. PMID: 24065705
    13. NR4A nuclear receptors are involved in negative selection of thymocytes, Treg differentiation and the development of Ly6C monocytes. Nur77 and Nurr1 attenuate atherosclerosis in mice whereas NOR-1 aggravates vascular lesion formation. PMID: 24005216
    14. Results indicate mutual antagonism between neuron-derived orphan receptor 1 (NOR1) and glucocorticoid receptor (GR) to be a key rheostat for peripheral metabolic signals to centrally control energy balance. PMID: 23897430
    15. Over-expression of neuron-derived orphan receptor-1 (NOR-1) exacerbates neointimal hyperplasia after vascular injury PMID: 23390133
    16. Insulin-mediated AKT phosphorylation was increased by NR4A3 hyperexpression and decreased following shRNA NR4A3 suppression. PMID: 23104421
    17. In mice, the orphan nuclear receptor Nor-1 activates proliferation of quiescent hepatocytes and is required for hepatocyte proliferation after partial hepatectomy. PMID: 23462179
    18. results suggest that Nr4a receptors have key roles in determining CD4(+) T cell fates in the thymus and thus contribute to immune homeostasis PMID: 23334790
    19. Nor-1 expression in skeletal muscle significantly improved glucose tolerance, oxygen consumption, and endurance/fatigue resistance, consistent with the acquisition of a more oxidative muscle phenotype. PMID: 22282471
    20. Promoting the expression of LXR alpha in Kupffer cells can elevate NOR-1 expression and inhibit the inflammatory reaction. PMID: 22152248
    21. NOR1 transactivates the Skp2 promoter through a nerve growth factor-induced clone B response element (NBRE). PMID: 21868379
    22. In response to purified LPS, strong upregulation of Nr4a3, but not of Nr4a1 or Nr4a2 was seen in mast cells PMID: 21621845
    23. Brain region-specific changes in glucocorticoid expression are strain dependent and contribute to depressive behavior in a Bax-deficient mouse model. PMID: 20851110
    24. Data show that NOR1 and LXRalpha were highly induced at mRNA and protein levels in dendritic cells upon infection with Newcastle Disease virus (NDV) or murine cytomegalovirus (MCMV). PMID: 21492741
    25. Reduced gene dosage of NR4A1 and NR4A3 in hypoallelic (NR4A1(+/-)NR4A3(-/-) or NR4A1(-/-)NR4A3(+/-)) mice below a critical threshold leads to a chronic myeloid malignancy. PMID: 21205929
    26. data describe a new role for LXR to regulate NOR-1 gene expression in adipocytes and demonstrate that these two nuclear receptors have an interdependent regulatory relationship, in addition to each being involved in the control of metabolic fuel usage. PMID: 19238156
    27. The orphan receptor Nor1 is involved in TCR-mediated cell death and thymocyte-negative selection. PMID: 12223510
    28. the NR4A subgroup mediates the genotoxic stress response PMID: 12709428
    29. Nor-1-deficient embryos fail to complete gastrulation and display abnormal expression of a number of early developmental markers and defects in growth or distribution of emerging mesoderm cells PMID: 13129926
    30. Ddata indicate that nor-1 plays a critical role in neuronal survival and axonal guidance in the developing murine hippocampus and that hippocampal dysgenesis in nor-1-/- mice may be an underlying cause of seizure susceptibility. PMID: 15456880
    31. a second ERK-dependent pathway, independent of MSK and CREB, was also required for the transcription of Nurr1 and Nor1 PMID: 15910281
    32. The in vivo induction of the NR4A family members by PTH suggests their involvement in, at least some, PTH-induced changes in bone metabolism. PMID: 15910753
    33. NR4A nuclear receptors NR4A1, NR4A2, NR4A3 are potential transcriptional mediators of inflammatory signals in activated macrophages PMID: 15964844
    34. prostaglandin A2 can serve as a transactivator of NOR1 PMID: 16141523
    35. Simultaneous deletion of Nr4a3 and Nr4a1 results in acute myeloid leukemia. PMID: 17515897
    36. FGF-8b induces the expression of Nor1 orphan nuclear receptors that are involved in mediating the growth promoting effect of FGF-8b in osteoblasts. PMID: 18809462
    37. Inhibition of adipocyte differentiation by Nur77, Nurr1, and Nor1. PMID: 18945812
    38. Blockade of MINOR expression dramatically decreases apoptosis in dendritic cells and enhance cancer vaccine efficacy. PMID: 19164597
    39. The significant induction (between 1 and 4h) of the NR4A genes in multiple tissues, was identified. PMID: 19465082
    40. These findings suggest that 5-HT2C receptor-independent proopiomelanocortin-derived peptides regulate the expression of hypothalamic NOR1, which is a novel modulator of feeding behavior and energy balance. PMID: 19523439

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Nuclear hormone receptor family, NR4 subfamily
  • 組織特異性：
    Ubiquitous. Highest levels of expression in brain. Widely expressed throughout the arcuate nucleus region of the hypothalamus, namely in AgRP neurons.
  • 數(shù)據(jù)庫鏈接：