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  4. Recombinant Mouse Protein FAM3C (Fam3c)

Recombinant Mouse Protein FAM3C (Fam3c)

  • 中文名稱：
    小鼠Fam3c重組蛋白
  • 貨號：
    CSB-YP835566MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Fam3c重組蛋白
  • 貨號：
    CSB-EP835566MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Fam3c重組蛋白
  • 貨號：
    CSB-EP835566MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Fam3c重組蛋白
  • 貨號：
    CSB-BP835566MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Fam3c重組蛋白
  • 貨號：
    CSB-MP835566MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Fam3c
  • Uniprot No.：
  • 別名：
    Fam3c; D6Wsu176e; IleiProtein FAM3C; Interleukin-like EMT inducer
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達(dá)區(qū)域：
    25-227
  • 氨基酸序列
    QVFEIK MDASLGNLFA RSALDSAIRS TKPPRYKCGI SKACPEKHFA FKMASGAANV VGPKICLEDN VLMSGVKNNV GRGINIALVN GKTGEVIDTK FFDMWGGDVA PFIEFLKTIQ DGTVVLMATY DDGATKLTDE ARRLIAELGS TSITSLGFRD NWVFCGGKGI KTKSPFEQHI KNNKETNKYE GWPEVVEMEG CIPQKQD
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be involved in retinal laminar formation. Promotes epithelial to mesenchymal transition.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that Ilei does not form interleukin-like four helix-bundle structures; Ilei exists as monomers and as covalent dimers; Ilei dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric Ilei appears to be involved in neoplastic invasiveness. PMID: 28751379
    2. In obese diabetic mice, FAM3C expression was reduced in the liver, and hepatic FAM3C restoration improved insulin resistance, hyperglycemia, and fatty liver. FAM3C overexpression increased the expression of heat shock factor 1 (HSF1), calmodulin (CaM), and phosphorylated Akt and reduced that of gluconeogenic and lipogenic genes in diabetic mouse livers with the suppression of gluconeogenesis and lipid deposition. PMID: 28246289
    3. Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta in the brain and the eventual development of Alzheimer's disease. PMID: 27256505
    4. FAM3C orthologous protein, may be involved in cell differentiation and proliferation during inner ear embryogenesis PMID: 15194199
    5. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors. PMID: 16959614

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  • 亞細(xì)胞定位：
    Secreted. Cytoplasmic vesicle.
  • 蛋白家族：
    FAM3 family
  • 組織特異性：
    Ubiquitously expressed, with highest levels in the retina. Up-regulated in mammary epithelial cells and hepatocytes undergoing epithelial to mesenchymal transition (at protein level).
  • 數(shù)據(jù)庫鏈接：