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  4. Recombinant Mouse Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 (Sohlh2)

Recombinant Mouse Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2 (Sohlh2)

  • 中文名稱：
    小鼠Sohlh2重組蛋白
  • 貨號：
    CSB-YP883993MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Sohlh2重組蛋白
  • 貨號：
    CSB-EP883993MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Sohlh2重組蛋白
  • 貨號：
    CSB-EP883993MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Sohlh2重組蛋白
  • 貨號：
    CSB-BP883993MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Sohlh2重組蛋白
  • 貨號：
    CSB-MP883993MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Sohlh2
  • Uniprot No.：
  • 別名：
    Sohlh2; Tohlh2; Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-467
  • 氨基酸序列
    MADRISTGEL GRRPGQGRVN LLLVGDATRY FLAGSMQKFF PSTAQITLTI SNVKKVAVLL AANSFDIIFL KVTSTLTAEE QEAAKLIRSG KKKNTHLLFA FVIPERLKGY VSEYGADISF SEPLTLEKVN TVIHYWKTYF TNTDMENTEL PPECRLYFQT SRSELGGRFS TDMFLCSELL KNDARLGLKA PLSSLDKSKQ ASFLHSTKEK LRRERIKSCC EQLRTLLPYV KGRKSDVASV IEATVDYVKQ VRESLSPAIM AQVTEAIQNN RRFSKRQMPI ELFLPFSATS QREDAMLTSA FSPVQEIQLL ADRGLNVYSM TAAGGALEGA VRGQPGSVSE SSIEDLYKTR VPSTARSLNS FHSVKYTSGT VSPHEAAART NQNISTYLPP TAPSVSNFIP QHCNAMLCPA RPTSPNCLCT PGHELAASSR AASASIFRGF RAASASDHQA SQPPALPSPQ PHDSSYF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription regulator of both male and female germline differentiation. Suppresses genes involved in spermatogonial stem cells maintenance, and induces genes important for spermatogonial differentiation. Coordinates oocyte differentiation without affecting meiosis I.
  • 基因功能參考文獻：
    1. Sohlh1 and Sohlh2 are essential regulators of oocyte differentiation but do not affect meiosis I. PMID: 28504655
    2. SOHLH2 is critical for the formation of synaptonemal complexes. PMID: 26869299
    3. Sohlh2 may inhibit oocyte apoptosis via c-kit/PI3K/Akt/Foxo3a signalling pathway PMID: 25773528
    4. SOHLH1 and SOHLH2 were able to directly and cooperatively repress STRA8 expression in cell lines in vitro through binding to its promoter. PMID: 25603532
    5. Our findings suggest that an SOHLH2/SOHLH1/SP1 ternary complex autonomously and cooperatively regulates Sohlh1 gene transcription through juxtaposed E- and GC-boxes during early spermatogenesis and oogenesis. PMID: 25003626
    6. Effects of BMP4 on mouse primordial follicle growth were assayed by follicle count and TUNEL labeling. The expression of phospho-SMAD1/5/8, Sohlh2, and c-kit were measured by immunohistochemistry, RT-PCR, and Western blotting. PMID: 23212987
    7. SOHLH1 and SOHLH2 directly stimulate Kit transcription in postnatal spermatogonia, thus activating the signaling involved in spermatogonia differentiation and spermatogenetic progression. PMID: 22328502
    8. Data suggest that a dynamic DNA CpG methylation in Sohlh2 and Figlalpha promoters, but not in the intron and exon sequences, is linked to regulation of gene expression, even though CpG islands are also present in their introns or exons. PMID: 21427160
    9. SOHLH1 and SOHLH2 suppress genes involved in spermatogonial stem cell maintenance, and induce genes important for spermatogonial differentiation. PMID: 22056784
    10. The expression pattern of SOHLH2 suggests that it may be a critical regulator of early germ cell development. PMID: 16765102
    11. Knockout of this protein causes degegneration of spermatogonia in mice. PMID: 18339773
    12. Sohlh2 is a critical factor for maintenance and differentiation of the oocyte during early oogenesis PMID: 18753606
    13. SOHLH2 might coordinate with SOHLH1 to control spermatogonial and oocyte genes, including Sohlh1, to promote the differentiation of KIT(+) germ cells in vivo. PMID: 19014927

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 組織特異性：
    Preferentially expressed in the adult ovary and testis. Expressed in the majority of spermatogonia in adult animals, but not in the most undifferentiated spermatogonial population.
  • 數(shù)據(jù)庫鏈接：