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  4. Recombinant Mouse Testis-specific serine/threonine-protein kinase 4 (Tssk4)

Recombinant Mouse Testis-specific serine/threonine-protein kinase 4 (Tssk4)

  • 中文名稱：
    小鼠Tssk4重組蛋白
  • 貨號：
    CSB-YP871977MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tssk4重組蛋白
  • 貨號：
    CSB-EP871977MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tssk4重組蛋白
  • 貨號：
    CSB-EP871977MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tssk4重組蛋白
  • 貨號：
    CSB-BP871977MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tssk4重組蛋白
  • 貨號：
    CSB-MP871977MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Tssk4
  • Uniprot No.：
  • 別名：
    Tssk4; Tssk5; Testis-specific serine/threonine-protein kinase 4; TSK-4; TSSK-4; Testis-specific kinase 4; EC 2.7.11.1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-328
  • 氨基酸序列
    MGKGDTSETA SATPAYRSVM EEYGYEVGKI IGHGSYGTVY EAYYTKQKVM VAVKIISKKK ASEDYLNKFL PREIQVMKVL RHKYLINFYQ AIETTSRVYI ILELAQGGDV LEWIQRYGAC AETLAGKWFS QMALGIAYLH SKGIVHRDLK LENLLLDKRE NVKISDFGFA KMVPSSQPVH SSPSYRQMNS LSHLSQTYCG SFAYACPEIL LGLPYNPFLS DTWSMGVILY TLVVARLPFD DTNLKKLLRE TQKEVTFPAN LTISQECKNL ILQLLRQSTK RATILDVLRD PWMLKFQPEQ PSNEIRLLEA MYQPTSSAKR HQSLEITT
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells. Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'.; Catalytically inactive.; Catalytically inactive.; Catalytically inactive.
  • 基因功能參考文獻：
    1. Testis-specific serine/threonine protein kinase 4 (Tssk4) phosphorylates Odf2 at Ser-76 PMID: 26961893
    2. Phosphorylated Tssk4 might participate in testis genes expressions by phosphorylating Crem at Ser-117. PMID: 26940607
    3. findings reveal that Tssk4 is required for maintaining the structural integrity of sperm flagellum and male fertility. PMID: 25361759
    4. HSP90 function abolished the catalytic activities of TSSK4 and -6 but did not significantly alter the specific activities of TSSK1 and -2. Inhibition of HSP90 resulted in increased TSSK ubiquitination and proteasomal degradation PMID: 23599433
    5. autophosphorylation at Thr-197 plays a critical role in maintaining Tssk4 kinase activity, which might be involved in spermiogenesis. PMID: 23054012

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  • 亞細胞定位：
    Cytoplasmic vesicle, secretory vesicle, acrosome. Cell projection, cilium, flagellum.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family
  • 組織特異性：
    [Isoform 1]: Expressed in spermatocytes and mature sperm (at protein level). Highly expressed in the spleen, heart and testis. Isoform 2, isoform 3, and isoform 4: Expressed at highest level in testis and heart and at low levels in the liver, spleen, kidn
  • 數(shù)據(jù)庫鏈接：