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  4. Recombinant Porphyromonas gingivalis Lys-gingipain (kgp), partial

Recombinant Porphyromonas gingivalis Lys-gingipain (kgp), partial

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  • 中文名稱：
    Recombinant Porphyromonas gingivalis Lys-gingipain(kgp),partial
  • 貨號：
    CSB-EP464342EXZ
  • 規(guī)格：
    ￥2328
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP464342EXZ could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) kgp.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP464342EXZ could indicate that this peptide derived from E.coli-expressed Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257) kgp.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
    kgp
  • Uniprot No.：
  • 別名：
    kgp; PGN_1728Lys-gingipain; EC 3.4.22.47; Lysine-specific cysteine proteinase Kgp) [Cleaved into: Lys-gingipain catalytic subunit; 39 kDa adhesin; 15 kDa adhesin; 44 kDa adhesin]
  • 種屬：
    Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / JCM 12257)
  • 蛋白長度：
    Partial
  • 來源：
    E.coli
  • 分子量：
    56.6kDa
  • 表達(dá)區(qū)域：
    229-594aa
  • 氨基酸序列
    DVYTDHGDLYNTPVRMLVVAGAKFKEALKPWLTWKAQKGFYLDVHYTDEAEVGTTNASIKAFIHKKYNDGLAASAAPVFLALVGDTDVISGEKGKKTKKVTDLYYSAVDGDYFPEMYTFRMSASSPEELTNIIDKVLMYEKATMPDKSYLEKALLIAGADSYWNPKIGQQTIKYAVQYYYNQDHGYTDVYSYPKAPYTGCYSHLNTGVGFANYTAHGSETSWADPSLTATQVKALTNKDKYFLAIGNCCVTAQFDYPQPCFGEVMTRVKEKGAYAYIGSSPNSYWGEDYYWSVGANAVFGVQPTFEGTSMGSYDATFLEDSYNTVNSIMWAGNLAATHAGNIGNITHIGAHYYWEAYHVLGDGSVM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽：
    N-terminal 6xHis-SUMO-tagged
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    3-7 business days
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產(chǎn)品描述：
        細(xì)胞表面半胱氨酸蛋白酶 RgpA、RgpB（Arg-gingipain）和 Kgp（Lys-gingipain）是牙齦膿胞桿菌的主要毒力因子，牙齦膿胞桿菌是導(dǎo)致破壞性牙周病的關(guān)鍵病原體。齦上蛋白酶具有蛋白酶和轉(zhuǎn)肽酶的功能，利用甘氨酰甘氨酸等小肽作為接受分子。
        華美生物大腸桿菌表達(dá)系統(tǒng)所表達(dá)的Porphyromonas gingivalis Lys-gingipain(kgp)表達(dá)區(qū)域為229-594aa，具有高穩(wěn)定性、高純度等特點，助您進(jìn)行相關(guān)研究。
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cysteine proteinase with a strong preference for substrates with Lys in the P1 position. Hydrolyzes bovine hemoglobin, bovine serum albumin, casein, human placental type I collagen and human IgA and IgG. Disrupts the functions of polymorphonuclear leukocytes. May act as a virulence factor in the development of peridontal disease. Involved in the coaggregation of P.gingivalis with other oral bacteria.
  • 基因功能參考文獻(xiàn)：
    1. a significant fraction of SPINK6-sensitive proteases in healthy saliva and confirmed the ability of gingipains to inactivate SPINK6 under ex vivo conditions PMID: 27354280
  • 亞細(xì)胞定位：
    [Lys-gingipain catalytic subunit]: Secreted.
  • 蛋白家族：
    Peptidase C25 family
  • 數(shù)據(jù)庫鏈接：