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  4. Recombinant Rabbit Ezrin (EZR), partial

Recombinant Rabbit Ezrin (EZR), partial

  • 中文名稱：
    小圓錐花果EZR重組蛋白
  • 貨號：
    CSB-YP007914RB
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小圓錐花果EZR重組蛋白
  • 貨號：
    CSB-EP007914RB
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小圓錐花果EZR重組蛋白
  • 貨號：
    CSB-EP007914RB-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小圓錐花果EZR重組蛋白
  • 貨號：
    CSB-BP007914RB
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小圓錐花果EZR重組蛋白
  • 貨號：
    CSB-MP007914RB
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    EZR; VIL2Ezrin; Cytovillin; Villin-2; p81
  • 種屬：
    Oryctolagus cuniculus (Rabbit)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that Mst4 phosphorylation of Thr545 of Acap4/Asap3 in parietal cells leads to Acap4/Asap3 binding to Ser66-phosphorylated ezrin (a cytoskeletal protein); phosphorylation of Thr545 of Acap4/Asap3 is required for relocation of H,K-ATPase to apical plasma membrane and acid secretion by parietal cells. (Mst4 = serine/threonine-protein kinase Mst4; Acap4/Asap3 = GTPase-activating protein Acap4/Asap3) PMID: 28808054
    2. Spatial control of proton pump H,K-ATPase docking at the apical membrane by phosphorylation-coupled ezrin-syntaxin 3 interaction. PMID: 25301939
    3. 1) NHE3 basal activity is regulated by a signaling complex that is controlled by sequential effects of two kinases, Akt and GSK-3, which act on a Ser cluster in the same NHE3 C-terminal domain that binds ezrin PMID: 24398676
    4. Ezrin-mediated F-actin interaction with the epithelial cell may direct membrane recruitment and cytoskeletal surface extension. PMID: 20505040
    5. relatively high turnover of ezrin T567 phosphorylation was observed in all three epithelia (gastric, kidney and intestine). PMID: 18480298

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  • 亞細(xì)胞定位：
    Apical cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell projection, microvillus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell projection, microvillus.
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